Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy

Kyu Sung Heo; Myung Ho Hyun; Yoon Jae Cho; Jae Jeong Ryoo

doi:10.1002/chir.20910

Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy

Kyu Sung Heo, Myung Ho Hyun, Yoon Jae Cho, Jae Jeong Ryoo

Department of Chemical Science Education

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

(R)-N-3,5-dinitrobenzoyl (DNB) leucine derived chiral selector was used as an HPLC chiral stationary phase for the resolution of various racemic amino acids derivatives. In this study, determination of optical purity of an amino acid derivative was performed by chiral high performance liquid chromatography and 1H and 13C NMR spectroscopy by using the DNB leucine derived chiral selector. The accuracy and precision of each optical purity value are calculated and the data are compared to each other. Chirality, 2011.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	Chirality
Volume	23
Issue number	4
DOIs	https://doi.org/10.1002/chir.20910
State	Published - Apr 2011

Keywords

13C NMR
1H NMR
chiral selector
DNB phenylglycinol
HPLC
optical purity

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10.1002/chir.20910

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title = "Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy",

abstract = "(R)-N-3,5-dinitrobenzoyl (DNB) leucine derived chiral selector was used as an HPLC chiral stationary phase for the resolution of various racemic amino acids derivatives. In this study, determination of optical purity of an amino acid derivative was performed by chiral high performance liquid chromatography and 1H and 13C NMR spectroscopy by using the DNB leucine derived chiral selector. The accuracy and precision of each optical purity value are calculated and the data are compared to each other. Chirality, 2011.",

keywords = "13C NMR, 1H NMR, chiral selector, DNB phenylglycinol, HPLC, optical purity",

author = "Heo, {Kyu Sung} and Hyun, {Myung Ho} and Cho, {Yoon Jae} and Ryoo, {Jae Jeong}",

year = "2011",

month = apr,

doi = "10.1002/chir.20910",

language = "English",

volume = "23",

pages = "281--286",

journal = "Chirality",

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T1 - Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy

AU - Heo, Kyu Sung

AU - Hyun, Myung Ho

AU - Cho, Yoon Jae

AU - Ryoo, Jae Jeong

PY - 2011/4

Y1 - 2011/4

N2 - (R)-N-3,5-dinitrobenzoyl (DNB) leucine derived chiral selector was used as an HPLC chiral stationary phase for the resolution of various racemic amino acids derivatives. In this study, determination of optical purity of an amino acid derivative was performed by chiral high performance liquid chromatography and 1H and 13C NMR spectroscopy by using the DNB leucine derived chiral selector. The accuracy and precision of each optical purity value are calculated and the data are compared to each other. Chirality, 2011.

AB - (R)-N-3,5-dinitrobenzoyl (DNB) leucine derived chiral selector was used as an HPLC chiral stationary phase for the resolution of various racemic amino acids derivatives. In this study, determination of optical purity of an amino acid derivative was performed by chiral high performance liquid chromatography and 1H and 13C NMR spectroscopy by using the DNB leucine derived chiral selector. The accuracy and precision of each optical purity value are calculated and the data are compared to each other. Chirality, 2011.

KW - 13C NMR

KW - 1H NMR

KW - chiral selector

KW - DNB phenylglycinol

KW - HPLC

KW - optical purity

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DO - 10.1002/chir.20910

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AN - SCOPUS:79952514116

SN - 0899-0042

VL - 23

SP - 281

EP - 286

JO - Chirality

JF - Chirality

IS - 4

ER -

Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy

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