TY - JOUR
T1 - Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing
T2 - Mechanical properties and effects on wound repair
AU - Jin, Sung Giu
AU - Kim, Kyeong Soo
AU - Kim, Dong Wuk
AU - Kim, Dong Shik
AU - Seo, Youn Gee
AU - Go, Toe Gyung
AU - Youn, Yu Seok
AU - Kim, Jong Oh
AU - Yong, Chul Soon
AU - Choi, Han Gon
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/1/30
Y1 - 2016/1/30
N2 - To develop a novel sodium fusidate-loaded triple polymer hydrogel dressing (TPHD), numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA. The effect of selected PVP:SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of sodium fusidate-loaded PVA-based TPHDs were assessed. As the ratio of PVP:SA increased in PVA-loaded TPHD, the swelling capacity, mechanical properties, drug release, permeation and deposition were improved. The TPHD containing PVA, PVP, SA and sodium fusidate at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties, release, permeation and deposition of drug. Within 24 h, 71.8 ± 1.3% of drug was released. It permeated 625.1 ± 81.2 μg/cm2 through the skin and deposited of 313.8 ± 24.1 μg/cm2 within 24 h. The results of in vivo pharmacodynamic studies showed that sodium fusidate-loaded TPHD was more effective in improving the repair process than was a commercial product. Thus, this sodium fusidate-loaded TPHD could be a novel tool in wound care.
AB - To develop a novel sodium fusidate-loaded triple polymer hydrogel dressing (TPHD), numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA. The effect of selected PVP:SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of sodium fusidate-loaded PVA-based TPHDs were assessed. As the ratio of PVP:SA increased in PVA-loaded TPHD, the swelling capacity, mechanical properties, drug release, permeation and deposition were improved. The TPHD containing PVA, PVP, SA and sodium fusidate at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties, release, permeation and deposition of drug. Within 24 h, 71.8 ± 1.3% of drug was released. It permeated 625.1 ± 81.2 μg/cm2 through the skin and deposited of 313.8 ± 24.1 μg/cm2 within 24 h. The results of in vivo pharmacodynamic studies showed that sodium fusidate-loaded TPHD was more effective in improving the repair process than was a commercial product. Thus, this sodium fusidate-loaded TPHD could be a novel tool in wound care.
KW - Deposition
KW - Permeation
KW - Sodium fusidate
KW - Triple polymer hydrogel wound dressing
KW - Wound repair effect
UR - http://www.scopus.com/inward/record.url?scp=84949802607&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2015.12.007
DO - 10.1016/j.ijpharm.2015.12.007
M3 - Article
C2 - 26657270
AN - SCOPUS:84949802607
SN - 0378-5173
VL - 497
SP - 114
EP - 122
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -