Development of biochip sensors for blood biomarkers specific to alzheimer’s disease diagnostics

Suhee Kim, Sang Hyuk Lee, Hye Jin Lee

Research output: Contribution to journalReview articlepeer-review

Abstract

The number of patients suffering from Alzheimer’s disease is increasing year after year and almost approaching 15% of the total elderly population. Although it is critical to detect the early stage of Alzheimer’s disease, which is a serious illness causing cognitive deficits, various existing diagnosis methods such as MRI, PET and CSF analysis could be the burdens for patients due to their high costs and long time to diagnosis. In order to tackle some of challenging issues for such existing diagnosis methods, extensive efforts have been made on developing fast and convenient biochip sensing methodologies for the diagnosis of Alzheimer’s disease with a droplet of patient biofluids (e.g., blood). In this mini-review, we highlight some of the latest biochip sensing technologies that could qualitatively and quantitatively analyze blood biomarkers used for Alzheimer’s disease diagnostics and discuss briefly related research trends and future aspects.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalApplied Chemistry for Engineering
Volume28
Issue number4
DOIs
StatePublished - Aug 2017

Keywords

  • Alzheimer’s disease
  • Biochip sensors
  • Blood biomarker
  • Surface plasmon resonance
  • Surface sandwich assay

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