@inproceedings{221d1819bf724f1985563c7e58365b29,
title = "Development of forward-looking ultrasound transducers for microbubble-aided intravascular ultrasound-enhanced thrombolysis",
abstract = "In this paper, we report the development of miniaturized forward-looking transducers for microbubble-mediated intravascular ultrasound-enhanced thrombolysis (UET). UET has shown its efficacy for thrombo-occlusive disease by enhancing penetration of thrombolytic drugs into clots, reducing the required dose. In this study, we adopted a previously-developed forward-looking, stacked type transducer for thrombolysis treatment with low dose (approximately 0.4 μg/ml)-recombinant tissue-plasminogen activator (rt-PA). The 650 kHz-prototype transducer with a concave lens enabled a confined ultrasound beam despite the small aperture (diameter <1.5 mm) with respect to the wavelength (2.2 mm), and peak-negative-pressure of 1.35 MPa with a corresponding mechanical index of 1.67 was achieved. In vitro thrombolysis tests using the developed transducer with microbubble infusion showed that local administration of low dose-recombinant tissue-plasminogen activator (rt-PA) results in a two-fold increase in average thrombolytic rate versus without rt-PA.",
keywords = "Catheter-directed ultrasound, Intravascular ultrasound, Microbubbles, Ultrasound-enhanced thrombolysis",
author = "Jinwook Kim and Lindsey, {Brooks D.} and Dayton, {Paul A.} and Chang, {Wei Yi} and Huaiyu Wu and Xiaoning Jiang",
note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE International Ultrasonics Symposium, IUS 2017 ; Conference date: 06-09-2017 Through 09-09-2017",
year = "2017",
month = oct,
day = "31",
doi = "10.1109/ULTSYM.2017.8092593",
language = "English",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
booktitle = "2017 IEEE International Ultrasonics Symposium, IUS 2017",
address = "United States",
}