Development of fully automated anterior chamber cell analysis based on image software

Tae Seen Kang, Yeongseop Lee, Seongjin Lee, Kyonghoon Kim, Woong sub Lee, Woohyuk Lee, Jin Hyun Kim, Yong Seop Han

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Optical coherence tomography (OCT) is a noninvasive method that can quickly and accurately examine the eye at the cellular level. Several studies have used OCT for analysis of anterior chamber cells. However, these studies have several limitations. This study was performed to supplement existing reports of automated analysis of anterior chamber cell images using spectral domain OCT (SD-OCT) and to compare this method with the Standardization of Uveitis Nomenclature (SUN) grading system. We analyzed 2398 anterior segment SD-OCT images from 34 patients using code written in Python. Cell density, size, and eccentricity were measured automatically. Increases in SUN grade were associated with significant cell density increases at all stages (p < 0.001). Significant differences were observed in eccentricity in uveitis, post-surgical inflammation, and vitreous hemorrhage (p < 0.001). Anterior segment SD-OCT is reliable, fast, and accurate means of anterior chamber cell analysis. This method showed a strong correlation with the SUN grade system. Also, eccentricity could be helpful as a supplementary evaluation tool.

Original languageEnglish
Article number10670
JournalScientific Reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021

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