Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier

Dong Wuk Kim, Jun Hyeok Kang, Dong Hoon Oh, Chul Soon Yong, Han Gon Choi

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

To develop a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) with improved oral bioavailability using gelatin as a solid carrier, the solid SMEDDS formulation was prepared by spray-drying the solutions containing liquid SMEDDS and gelatin. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Transcutol HP (12.5/80/7.5) with 2 w/v flurbiprofen, gave a z-average diameter of about 100nm. The flurbiprofen-loaded solid SMEDDS formulation gave a larger emulsion droplet size compared to liquid SMEDDS. Unlike conventional solid SMEDDS, it produced a kind of microcapsule in which liquid SMEDDS was not absorbed onto the surfaces of carrier but formed together with carrier in it. However, the drug was in an amorphous state in it like conventional solid SMEDDS. It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalJournal of Microencapsulation
Volume29
Issue number4
DOIs
StatePublished - Jun 2012

Keywords

  • Bioavailability
  • Flurbiprofen
  • Gelatin, solid carrier
  • Solid self-microemulsifying drug delivery system

Fingerprint

Dive into the research topics of 'Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier'. Together they form a unique fingerprint.

Cite this