Abstract
We developed new surface acoustic wave (SAW) sensors to detect protein molecules in liquid solutions applying a particular antibody thin film on the delay line of transverse SAW devices. The sensor consists of twin SAW delay lines operating at 100 MHz, a sensitive channel and a reference channel, fabricated on 36 degrees rotated Y-cut X-propagation LiTaO3 piezoelectric single crystals. Each delay line is configured as an oscillator. The relative change in the frequency of the two oscillators is monitored to measure the concentration of the antigen molecules in the chemical solutions. The antibody investigated was human-immuno-globulin G (HigG) to hold the antigens (anti-HigG) in the protein solution to be measured. The sensor showed linear response to the mass loading effects of the anti-HigG molecules with the sensitivity up to 16.7 ng/ml/Hz.
| Original language | English |
|---|---|
| Pages (from-to) | 1077-1082 |
| Number of pages | 6 |
| Journal | Key Engineering Materials |
| Volume | 270-273 |
| Issue number | II |
| DOIs | |
| State | Published - 2004 |
| Event | Proceedings of the 11th Asian Pacific Conference on Nondestructive Testing - Jeju Island, Korea, Republic of Duration: 3 Nov 2003 → 7 Nov 2003 |
Keywords
- LiTaO
- Oscillator
- Protein sensor
- SH-SAW