Development of thymic carcinoma in transgenic mice expressing SV40 T antigen

Woong Yang Park; Jong Il Kim; Eun Hee Shim; Won Ha Lee; Soon Hee Kim; Jung Wook Seo; Ja June Jang; Jeong Sun Seo

doi:10.1016/0304-3835(96)04413-8

Development of thymic carcinoma in transgenic mice expressing SV40 T antigen

Woong Yang Park, Jong Il Kim, Eun Hee Shim, Won Ha Lee, Soon Hee Kim, Jung Wook Seo, Ja June Jang, Jeong Sun Seo

Seoul National University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We produced transgenic mice using SV40 Tag gene under the control of its own enhancer and promoter. Three transgenic lines (SNU-SVT125, 127, 248) consistently developed thymic carcinoma as well as choroid plexus carcinoma and dysplastic renal tubule. In SNU-SVT248 line, SV40 Tag transgene was expressed at thymus, spleen and kidney. Thymic epithelium showed high level expression of SV40 Tag in immunohistochemistry. Histopathological and electron microscopic analysis revealed that poorly differentiated carcinoma was derived from type 2 to 4 thymic epithelial cell. Our transgenic mice would provide a model for studies on the pathogenesis of thymic carcinoma and on the regulation of thymopoiesis by epithelial cells.

Original language	English
Pages (from-to)	293-300
Number of pages	8
Journal	Cancer Letters
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(96)04413-8
State	Published - 22 Oct 1996

Keywords

SV40 Tag
Thymic carcinoma
Thymic epithelial cell line
Transgenic mice

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10.1016/0304-3835(96)04413-8

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title = "Development of thymic carcinoma in transgenic mice expressing SV40 T antigen",

abstract = "We produced transgenic mice using SV40 Tag gene under the control of its own enhancer and promoter. Three transgenic lines (SNU-SVT125, 127, 248) consistently developed thymic carcinoma as well as choroid plexus carcinoma and dysplastic renal tubule. In SNU-SVT248 line, SV40 Tag transgene was expressed at thymus, spleen and kidney. Thymic epithelium showed high level expression of SV40 Tag in immunohistochemistry. Histopathological and electron microscopic analysis revealed that poorly differentiated carcinoma was derived from type 2 to 4 thymic epithelial cell. Our transgenic mice would provide a model for studies on the pathogenesis of thymic carcinoma and on the regulation of thymopoiesis by epithelial cells.",

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author = "Park, {Woong Yang} and Kim, {Jong Il} and Shim, {Eun Hee} and Lee, {Won Ha} and Kim, {Soon Hee} and Seo, {Jung Wook} and Jang, {Ja June} and Seo, {Jeong Sun}",

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doi = "10.1016/0304-3835(96)04413-8",

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T1 - Development of thymic carcinoma in transgenic mice expressing SV40 T antigen

AU - Park, Woong Yang

AU - Kim, Jong Il

AU - Shim, Eun Hee

AU - Lee, Won Ha

AU - Kim, Soon Hee

AU - Seo, Jung Wook

AU - Jang, Ja June

AU - Seo, Jeong Sun

PY - 1996/10/22

Y1 - 1996/10/22

N2 - We produced transgenic mice using SV40 Tag gene under the control of its own enhancer and promoter. Three transgenic lines (SNU-SVT125, 127, 248) consistently developed thymic carcinoma as well as choroid plexus carcinoma and dysplastic renal tubule. In SNU-SVT248 line, SV40 Tag transgene was expressed at thymus, spleen and kidney. Thymic epithelium showed high level expression of SV40 Tag in immunohistochemistry. Histopathological and electron microscopic analysis revealed that poorly differentiated carcinoma was derived from type 2 to 4 thymic epithelial cell. Our transgenic mice would provide a model for studies on the pathogenesis of thymic carcinoma and on the regulation of thymopoiesis by epithelial cells.

AB - We produced transgenic mice using SV40 Tag gene under the control of its own enhancer and promoter. Three transgenic lines (SNU-SVT125, 127, 248) consistently developed thymic carcinoma as well as choroid plexus carcinoma and dysplastic renal tubule. In SNU-SVT248 line, SV40 Tag transgene was expressed at thymus, spleen and kidney. Thymic epithelium showed high level expression of SV40 Tag in immunohistochemistry. Histopathological and electron microscopic analysis revealed that poorly differentiated carcinoma was derived from type 2 to 4 thymic epithelial cell. Our transgenic mice would provide a model for studies on the pathogenesis of thymic carcinoma and on the regulation of thymopoiesis by epithelial cells.

KW - SV40 Tag

KW - Thymic carcinoma

KW - Thymic epithelial cell line

KW - Transgenic mice

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DO - 10.1016/0304-3835(96)04413-8

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Development of thymic carcinoma in transgenic mice expressing SV40 T antigen

Abstract

Keywords

UN SDGs

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