Abstract
Age-related changes in the vimentin filaments were studied by immunohistochemistry and electron microscopy. In 2-week-old rats, cells showed only weak labelling for vimentin. A few intermediate filaments but well-developed rough endoplasmic reticulum and Golgi apparatus were observed in the cytoplasm. As the age of the rats advanced from 4-weeks to adulthood, labelling intensity increased and the cytoplasm of articular-disc cells was gradually filled with intermediate filaments surrounding degraded cytoplasmic organelles in the cytosol. Articular-disc cells in adult rats showed intense vimentin labelling and their cytoplasm was filled with closely packed intermediate filaments aligned in alternating layers. This age-related accumulation of vimentin filaments in articular-disc cells may be an adaptive response to compressive forces.
| Original language | English |
|---|---|
| Pages (from-to) | 579-583 |
| Number of pages | 5 |
| Journal | Archives of Oral Biology |
| Volume | 43 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1998 |
Keywords
- Ageing
- Articular disc
- Immunohistochemistry
- Squamosomandibular joint
- Ultrastructure
- Vimentin filaments