Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines

Sung Kyu Choi; Yeong Geun Lee; Rong Bo Wang; Hyoung Geun Kim; Dahye Yoon; Dae Young Lee; Yeon Ju Kim; Nam In Baek

doi:10.1186/s13765-020-00524-y

Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines

Sung Kyu Choi, Yeong Geun Lee, Rong Bo Wang, Hyoung Geun Kim, Dahye Yoon, Dae Young Lee, Yeon Ju Kim, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Repeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the 1D and 2D NMR data, especially from HMBC and NOESY experiments. In addition, MTT assays and cell viability experiments verified the cytotoxicity of the isolated dibenzocyclooctadiene lignans against the human cancer cell lines AGS, HeLa, and HT-29.

Original language	English
Article number	39
Journal	Applied Biological Chemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1186/s13765-020-00524-y
State	Published - 1 Dec 2020

Keywords

Angeloyl gomisin H
Cytotoxicity
Dibenzocyclooctadiene lignan
Human cancer cells
Schisandra chinensis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13765-020-00524-y

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title = "Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines",

abstract = "Repeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the 1D and 2D NMR data, especially from HMBC and NOESY experiments. In addition, MTT assays and cell viability experiments verified the cytotoxicity of the isolated dibenzocyclooctadiene lignans against the human cancer cell lines AGS, HeLa, and HT-29.",

keywords = "Angeloyl gomisin H, Cytotoxicity, Dibenzocyclooctadiene lignan, Human cancer cells, Schisandra chinensis",

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doi = "10.1186/s13765-020-00524-y",

language = "English",

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T1 - Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines

AU - Choi, Sung Kyu

AU - Lee, Yeong Geun

AU - Wang, Rong Bo

AU - Kim, Hyoung Geun

AU - Yoon, Dahye

AU - Lee, Dae Young

AU - Kim, Yeon Ju

AU - Baek, Nam In

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Repeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the 1D and 2D NMR data, especially from HMBC and NOESY experiments. In addition, MTT assays and cell viability experiments verified the cytotoxicity of the isolated dibenzocyclooctadiene lignans against the human cancer cell lines AGS, HeLa, and HT-29.

AB - Repeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the 1D and 2D NMR data, especially from HMBC and NOESY experiments. In addition, MTT assays and cell viability experiments verified the cytotoxicity of the isolated dibenzocyclooctadiene lignans against the human cancer cell lines AGS, HeLa, and HT-29.

KW - Angeloyl gomisin H

KW - Cytotoxicity

KW - Dibenzocyclooctadiene lignan

KW - Human cancer cells

KW - Schisandra chinensis

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U2 - 10.1186/s13765-020-00524-y

DO - 10.1186/s13765-020-00524-y

M3 - Article

AN - SCOPUS:85088153473

SN - 2468-0834

VL - 63

JO - Applied Biological Chemistry

JF - Applied Biological Chemistry

IS - 1

M1 - 39

ER -

Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines

Abstract

Keywords

UN SDGs

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