Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer

Jong Hyun Kim, Chan Hyeong Lee, Moon Chang Baek

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called exosomes. Exosomes are released from a broad spectrum of cell types and serve as functional mediators under physiological or pathological conditions. Hence, blocking the release of exosome bio carriers may prove useful for slowing the progression of certain types of cancers. Therefore, efforts are being made to develop exosome inhibitors to be used both as research tools and as therapies in clinical trials. Thus, studies on exosomes may lead to a breakthrough in cancer research, for which new clinical targets for different types of cancers are urgently needed. In this review, we briefly outline exosome inhibitors and discuss their modes of action and potential for use as therapeutic tools for cancer.

Original languageEnglish
Pages (from-to)1833-1843
Number of pages11
JournalExperimental and Molecular Medicine
Volume54
Issue number11
DOIs
StatePublished - Nov 2022

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