TY - JOUR
T1 - Dissecting exosome inhibitors
T2 - therapeutic insights into small-molecule chemicals against cancer
AU - Kim, Jong Hyun
AU - Lee, Chan Hyeong
AU - Baek, Moon Chang
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called exosomes. Exosomes are released from a broad spectrum of cell types and serve as functional mediators under physiological or pathological conditions. Hence, blocking the release of exosome bio carriers may prove useful for slowing the progression of certain types of cancers. Therefore, efforts are being made to develop exosome inhibitors to be used both as research tools and as therapies in clinical trials. Thus, studies on exosomes may lead to a breakthrough in cancer research, for which new clinical targets for different types of cancers are urgently needed. In this review, we briefly outline exosome inhibitors and discuss their modes of action and potential for use as therapeutic tools for cancer.
AB - Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called exosomes. Exosomes are released from a broad spectrum of cell types and serve as functional mediators under physiological or pathological conditions. Hence, blocking the release of exosome bio carriers may prove useful for slowing the progression of certain types of cancers. Therefore, efforts are being made to develop exosome inhibitors to be used both as research tools and as therapies in clinical trials. Thus, studies on exosomes may lead to a breakthrough in cancer research, for which new clinical targets for different types of cancers are urgently needed. In this review, we briefly outline exosome inhibitors and discuss their modes of action and potential for use as therapeutic tools for cancer.
UR - http://www.scopus.com/inward/record.url?scp=85142938711&partnerID=8YFLogxK
U2 - 10.1038/s12276-022-00898-7
DO - 10.1038/s12276-022-00898-7
M3 - Review article
C2 - 36446847
AN - SCOPUS:85142938711
SN - 1226-3613
VL - 54
SP - 1833
EP - 1843
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 11
ER -