Distinct volumetric features of cerebrospinal fluid distribution in idiopathic normal-pressure hydrocephalus and Alzheimer’s disease

Jaehwan Han, Myoung Nam Kim, Ho Won Lee, Shin Young Jeong, Sang Woo Lee, Uicheul Yoon, Kyunghun Kang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective: The aims of the study were to measure the cerebrospinal fluid (CSF) volumes in the lateral ventricle, high-convexity subarachnoid space, and Sylvian fissure region in patients with idiopathic normal-pressure hydrocephalus (INPH) and Alzheimer’s disease (AD), and to evaluate differences in these volumes between INPH and AD groups and healthy controls. Methods: Forty-nine INPH patients, 59 AD patients, and 26 healthy controls were imaged with automated three-dimensional volumetric MRI. Results: INPH patients had larger lateral ventricles and CSF spaces of the Sylvian fissure region and smaller high-convexity subarachnoid spaces than other groups, and AD patients had larger lateral ventricles and CSF spaces of the Sylvian fissure region than the control group. The INPH group showed a negative correlation between lateral ventricle and high-convexity subarachnoid space volumes, while the AD group showed a positive correlation between lateral ventricle volume and volume for CSF spaces of the Sylvian fissure region. The ratio of lateral ventricle to high-convexity subarachnoid space volumes yielded an area under the curve of 0.990, differentiating INPH from AD. Conclusions: Associations between CSF volumes suggest that there might be different mechanisms between INPH and AD to explain their respective lateral ventricular dilations. The ratio of lateral ventricle to high-convexity subarachnoid space volumes distinguishes INPH from AD with good diagnostic sensitivity and specificity. We propose to refer to this ratio as the VOSS (ventricle over subarachnoid space) index.

Original languageEnglish
Article number66
JournalFluids and Barriers of the CNS
Volume19
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Alzheimer’s disease
  • Cerebrospinal fluid space
  • Idiopathic normal-pressure hydrocephalus
  • Magnetic resonance imaging

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