Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity

Thi Men Ngo; Phuong Thao Tran; Le Son Hoang; Jeong Hyung Lee; Byung Sun Min; Jeong Ah Kim

doi:10.1080/14786419.2019.1596098

Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity

Thi Men Ngo, Phuong Thao Tran, Le Son Hoang, Jeong Hyung Lee, Byung Sun Min, Jeong Ah Kim

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14–16) together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC₅₀ value of 3.4 ± 1.2 μM.

Original language	English
Pages (from-to)	726-732
Number of pages	7
Journal	Natural Product Research
Volume	35
Issue number	5
DOIs	https://doi.org/10.1080/14786419.2019.1596098
State	Published - 2021

Keywords

anti-inflammatory activity
diterpene alkaloid
nitric oxide production
Salvia miltiorrhiza

Access to Document

10.1080/14786419.2019.1596098

Cite this

@article{88de7be3c84a4f0fa854535b275200a7,

title = "Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity",

abstract = "Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14–16) together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.",

keywords = "anti-inflammatory activity, diterpene alkaloid, nitric oxide production, Salvia miltiorrhiza",

author = "Ngo, {Thi Men} and Tran, {Phuong Thao} and Hoang, {Le Son} and Lee, {Jeong Hyung} and Min, {Byung Sun} and Kim, {Jeong Ah}",

note = "Publisher Copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

doi = "10.1080/14786419.2019.1596098",

language = "English",

volume = "35",

pages = "726--732",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity

AU - Ngo, Thi Men

AU - Tran, Phuong Thao

AU - Hoang, Le Son

AU - Lee, Jeong Hyung

AU - Min, Byung Sun

AU - Kim, Jeong Ah

PY - 2021

Y1 - 2021

N2 - Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14–16) together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.

AB - Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14–16) together with twelve known compounds (1, 2, 4–13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.

KW - anti-inflammatory activity

KW - diterpene alkaloid

KW - nitric oxide production

KW - Salvia miltiorrhiza

UR - http://www.scopus.com/inward/record.url?scp=85064004760&partnerID=8YFLogxK

U2 - 10.1080/14786419.2019.1596098

DO - 10.1080/14786419.2019.1596098

M3 - Article

C2 - 30961363

AN - SCOPUS:85064004760

SN - 1478-6419

VL - 35

SP - 726

EP - 732

JO - Natural Product Research

JF - Natural Product Research

IS - 5

ER -

Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this