DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase

Rajesh Kasiviswanathan; Jae Ho Shin; Zvi Kelman

doi:10.1128/JB.00168-06

DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase

Rajesh Kasiviswanathan
, Jae Ho Shin
, Zvi Kelman

University of Maryland, College Park
St. Jude Children Research Hospital

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.

Original language	English
Pages (from-to)	4577-4580
Number of pages	4
Journal	Journal of Bacteriology
Volume	188
Issue number	12
DOIs	https://doi.org/10.1128/JB.00168-06
State	Published - Jun 2006

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title = "DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase",

abstract = "The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.",

author = "Rajesh Kasiviswanathan and Shin, \{Jae Ho\} and Zvi Kelman",

year = "2006",

month = jun,

doi = "10.1128/JB.00168-06",

language = "English",

volume = "188",

pages = "4577--4580",

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publisher = "American Society for Microbiology",

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AU - Kasiviswanathan, Rajesh

AU - Shin, Jae Ho

AU - Kelman, Zvi

PY - 2006/6

Y1 - 2006/6

N2 - The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.

AB - The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.

UR - https://www.scopus.com/pages/publications/33744982092

U2 - 10.1128/JB.00168-06

DO - 10.1128/JB.00168-06

M3 - Article

C2 - 16740965

AN - SCOPUS:33744982092

SN - 0021-9193

VL - 188

SP - 4577

EP - 4580

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 12

ER -

DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase

Abstract

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