Down-regulation of mortalin exacerbates aβ-mediated mitochondrial fragmentation and dysfunction

So Jung Park; Ji Hyun Shin; Jae In Jeong; Ji Hoon Song; Yoon Kyung Jo; Eun Sung Kim; Eunjoo H. Lee; Jung Jin Hwang; Eun Kyung Lee; Sun Ju Chung; Jae Young Koh; Dong Gyu Jo; Dong Hyung Cho

doi:10.1074/jbc.M113.492587

Down-regulation of mortalin exacerbates aβ-mediated mitochondrial fragmentation and dysfunction

So Jung Park, Ji Hyun Shin, Jae In Jeong, Ji Hoon Song, Yoon Kyung Jo, Eun Sung Kim, Eunjoo H. Lee, Jung Jin Hwang, Eun Kyung Lee, Sun Ju Chung, Jae Young Koh, Dong Gyu Jo, Dong Hyung Cho

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: Mitochondrial dysfunction is associated with neuronal disorders, and mitochondrial dynamics are altered in neurodegenerative diseases. Results: Inhibition of mortalin potentiates amyloid-β-mediated mitochondrial dysfunction and cytotoxicity. Conclusion: Inhibition of mortalin could lead to mitochondrial dysfunction through mitochondrial fragmentation. Significance: Activation of mortalin may antagonize the progression of Aβ-mediated neuronal injury in which mitochondrial dysfunction has a key role.

Original language	English
Pages (from-to)	2195-2204
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	4
DOIs	https://doi.org/10.1074/jbc.M113.492587
State	Published - 24 Jan 2014

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title = "Down-regulation of mortalin exacerbates aβ-mediated mitochondrial fragmentation and dysfunction",

abstract = "Background: Mitochondrial dysfunction is associated with neuronal disorders, and mitochondrial dynamics are altered in neurodegenerative diseases. Results: Inhibition of mortalin potentiates amyloid-β-mediated mitochondrial dysfunction and cytotoxicity. Conclusion: Inhibition of mortalin could lead to mitochondrial dysfunction through mitochondrial fragmentation. Significance: Activation of mortalin may antagonize the progression of Aβ-mediated neuronal injury in which mitochondrial dysfunction has a key role.",

author = "Park, \{So Jung\} and Shin, \{Ji Hyun\} and Jeong, \{Jae In\} and Song, \{Ji Hoon\} and Jo, \{Yoon Kyung\} and Kim, \{Eun Sung\} and Lee, \{Eunjoo H.\} and Hwang, \{Jung Jin\} and Lee, \{Eun Kyung\} and Chung, \{Sun Ju\} and Koh, \{Jae Young\} and Jo, \{Dong Gyu\} and Cho, \{Dong Hyung\}",

year = "2014",

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doi = "10.1074/jbc.M113.492587",

language = "English",

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TY - JOUR

T1 - Down-regulation of mortalin exacerbates aβ-mediated mitochondrial fragmentation and dysfunction

AU - Park, So Jung

AU - Shin, Ji Hyun

AU - Jeong, Jae In

AU - Song, Ji Hoon

AU - Jo, Yoon Kyung

AU - Kim, Eun Sung

AU - Lee, Eunjoo H.

AU - Hwang, Jung Jin

AU - Lee, Eun Kyung

AU - Chung, Sun Ju

AU - Koh, Jae Young

AU - Jo, Dong Gyu

AU - Cho, Dong Hyung

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Background: Mitochondrial dysfunction is associated with neuronal disorders, and mitochondrial dynamics are altered in neurodegenerative diseases. Results: Inhibition of mortalin potentiates amyloid-β-mediated mitochondrial dysfunction and cytotoxicity. Conclusion: Inhibition of mortalin could lead to mitochondrial dysfunction through mitochondrial fragmentation. Significance: Activation of mortalin may antagonize the progression of Aβ-mediated neuronal injury in which mitochondrial dysfunction has a key role.

AB - Background: Mitochondrial dysfunction is associated with neuronal disorders, and mitochondrial dynamics are altered in neurodegenerative diseases. Results: Inhibition of mortalin potentiates amyloid-β-mediated mitochondrial dysfunction and cytotoxicity. Conclusion: Inhibition of mortalin could lead to mitochondrial dysfunction through mitochondrial fragmentation. Significance: Activation of mortalin may antagonize the progression of Aβ-mediated neuronal injury in which mitochondrial dysfunction has a key role.

UR - https://www.scopus.com/pages/publications/84893146602

U2 - 10.1074/jbc.M113.492587

DO - 10.1074/jbc.M113.492587

M3 - Article

C2 - 24324263

AN - SCOPUS:84893146602

SN - 0021-9258

VL - 289

SP - 2195

EP - 2204

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 4

ER -

Down-regulation of mortalin exacerbates aβ-mediated mitochondrial fragmentation and dysfunction

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