Dual-mode T1 and T2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: Synthesis, characterization, and in vivo application

Tirusew Tegafaw, Wenlong Xu, Md Wasi Ahmad, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Tae Jeong Kim, Gang Ho Lee

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

A new type of dual-mode T1 and T2 magnetic resonance imaging (MRI) contrast agent based on mixed lanthanide oxide nanoparticles was synthesized. Gd3+ (8S7/2) plays an important role in T1 MRI contrast agents because of its large electron spin magnetic moment resulting from its seven unpaired 4f-electrons, and Dy3+ (6H15/2) has the potential to be used in T2 MRI contrast agents because of its very large total electron magnetic moment: among lanthanide oxide nanoparticles, Dy2O3 nanoparticles have the largest magnetic moments at room temperature. Using these properties of Gd3+ and Dy3+ and their oxide nanoparticles, ultrasmall mixed gadolinium-dysprosium oxide (GDO) nanoparticles were synthesized and their potential to act as a dual-mode T1 and T2 MRI contrast agent was investigated in vitro and in vivo. The D-glucuronic acid coated GDO nanoparticles (davg = 1.0 nm) showed large r1 and r2 values (r2/r1 ≈ 6.6) and as a result clear dose-dependent contrast enhancements in R1 and R2 map images. Finally, the dual-mode imaging capability of the nanoparticles was confirmed by obtaining in vivo T1 and T2 MR images.

Original languageEnglish
Article number365102
JournalNanotechnology
Volume26
Issue number36
DOIs
StatePublished - 11 Sep 2015

Keywords

  • MRI
  • dual-mode imaging
  • gadolinium-dysprosium
  • mixed nanoparticle

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