Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Wen Chi Yin; Thevagi Satkunendran; Rong Mo; Sorana Morrissy; Xiaoyun Zhang; Eunice Shiao Huang; Liis Uusküla-Reimand; Huayun Hou; Joe Eun Son; Weifan Liu; Yulu C. Liu; Jianing Zhang; Jessica Parker; Xin Wang; Hamza Farooq; Hayden Selvadurai; Xin Chen; Elly Sau-Wai Ngan; Steven Y. Cheng; Peter B. Dirks; Stephane Angers; Michael D. Wilson; Michael D. Taylor; Chi chung Hui

doi:10.1016/j.devcel.2018.11.015

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Wen Chi Yin, Thevagi Satkunendran, Rong Mo, Sorana Morrissy, Xiaoyun Zhang, Eunice Shiao Huang, Liis Uusküla-Reimand, Huayun Hou, Joe Eun Son, Weifan Liu, Yulu C. Liu, Jianing Zhang, Jessica Parker, Xin Wang, Hamza Farooq, Hayden Selvadurai, Xin Chen, Elly Sau-Wai Ngan, Steven Y. Cheng, Peter B. DirksStephane Angers, Michael D. Wilson, Michael D. Taylor, Chi chung Hui

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Yin et al. demonstrate that SUFU exerts both tumor-promoting and -suppressive functions in the SHH subgroup of medulloblastoma. Performing transcriptomic and genomic analyses in the Sufu;Spop double knockout medulloblastoma mouse model, the authors unveil the GLI2 targetome and identify ATOH1 as a key molecular accomplice of GLI2 in medulloblastoma.

Original language	English
Pages (from-to)	167-183.e5
Journal	Developmental Cell
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2018.11.015
State	Published - 28 Jan 2019

Keywords

GLI2
Hedgehog signaling
SPOP
SUFU
medulloblastoma
mouse model
targetome

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10.1016/j.devcel.2018.11.015

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Yin, W. C., Satkunendran, T., Mo, R., Morrissy, S., Zhang, X., Huang, E. S., Uusküla-Reimand, L., Hou, H., Son, J. E., Liu, W., Liu, Y. C., Zhang, J., Parker, J., Wang, X., Farooq, H., Selvadurai, H., Chen, X., Sau-Wai Ngan, E., Cheng, S. Y., ... Hui, C. C. (2019). Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma. Developmental Cell, 48(2), 167-183.e5. https://doi.org/10.1016/j.devcel.2018.11.015

@article{36e8f160a9754a03ad37d36d96ab5730,

title = "Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma",

abstract = "Yin et al. demonstrate that SUFU exerts both tumor-promoting and -suppressive functions in the SHH subgroup of medulloblastoma. Performing transcriptomic and genomic analyses in the Sufu;Spop double knockout medulloblastoma mouse model, the authors unveil the GLI2 targetome and identify ATOH1 as a key molecular accomplice of GLI2 in medulloblastoma.",

keywords = "GLI2, Hedgehog signaling, SPOP, SUFU, medulloblastoma, mouse model, targetome",

author = "Yin, {Wen Chi} and Thevagi Satkunendran and Rong Mo and Sorana Morrissy and Xiaoyun Zhang and Huang, {Eunice Shiao} and Liis Uusk{\"u}la-Reimand and Huayun Hou and Son, {Joe Eun} and Weifan Liu and Liu, {Yulu C.} and Jianing Zhang and Jessica Parker and Xin Wang and Hamza Farooq and Hayden Selvadurai and Xin Chen and {Sau-Wai Ngan}, Elly and Cheng, {Steven Y.} and Dirks, {Peter B.} and Stephane Angers and Wilson, {Michael D.} and Taylor, {Michael D.} and Hui, {Chi chung}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

day = "28",

doi = "10.1016/j.devcel.2018.11.015",

language = "English",

volume = "48",

pages = "167--183.e5",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "2",

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Yin, WC, Satkunendran, T, Mo, R, Morrissy, S, Zhang, X, Huang, ES, Uusküla-Reimand, L, Hou, H, Son, JE, Liu, W, Liu, YC, Zhang, J, Parker, J, Wang, X, Farooq, H, Selvadurai, H, Chen, X, Sau-Wai Ngan, E, Cheng, SY, Dirks, PB, Angers, S, Wilson, MD, Taylor, MD & Hui, CC 2019, 'Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma', Developmental Cell, vol. 48, no. 2, pp. 167-183.e5. https://doi.org/10.1016/j.devcel.2018.11.015

TY - JOUR

T1 - Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

AU - Yin, Wen Chi

AU - Satkunendran, Thevagi

AU - Mo, Rong

AU - Morrissy, Sorana

AU - Zhang, Xiaoyun

AU - Huang, Eunice Shiao

AU - Uusküla-Reimand, Liis

AU - Hou, Huayun

AU - Son, Joe Eun

AU - Liu, Weifan

AU - Liu, Yulu C.

AU - Zhang, Jianing

AU - Parker, Jessica

AU - Wang, Xin

AU - Farooq, Hamza

AU - Selvadurai, Hayden

AU - Chen, Xin

AU - Sau-Wai Ngan, Elly

AU - Cheng, Steven Y.

AU - Dirks, Peter B.

AU - Angers, Stephane

AU - Wilson, Michael D.

AU - Taylor, Michael D.

AU - Hui, Chi chung

PY - 2019/1/28

Y1 - 2019/1/28

N2 - Yin et al. demonstrate that SUFU exerts both tumor-promoting and -suppressive functions in the SHH subgroup of medulloblastoma. Performing transcriptomic and genomic analyses in the Sufu;Spop double knockout medulloblastoma mouse model, the authors unveil the GLI2 targetome and identify ATOH1 as a key molecular accomplice of GLI2 in medulloblastoma.

AB - Yin et al. demonstrate that SUFU exerts both tumor-promoting and -suppressive functions in the SHH subgroup of medulloblastoma. Performing transcriptomic and genomic analyses in the Sufu;Spop double knockout medulloblastoma mouse model, the authors unveil the GLI2 targetome and identify ATOH1 as a key molecular accomplice of GLI2 in medulloblastoma.

KW - GLI2

KW - Hedgehog signaling

KW - SPOP

KW - SUFU

KW - medulloblastoma

KW - mouse model

KW - targetome

UR - http://www.scopus.com/inward/record.url?scp=85060064062&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2018.11.015

DO - 10.1016/j.devcel.2018.11.015

M3 - Article

C2 - 30554998

AN - SCOPUS:85060064062

SN - 1534-5807

VL - 48

SP - 167-183.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 2

ER -

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

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