Dummy run of quality assurance program before prospective study of hippocampus-sparing whole-brain radiotherapy and simultaneous integrated boost for multiple brain metastases from non-small cell lung cancer: Korean radiation oncology Group (KROG) 17-06 study

Eunah Chung, Jae Myoung Noh, Kyu Chan Lee, Jin Hee Kim, Weon Kuu Chung, Yang Gun Suh, Jung Ae Lee, Ki Ho Seol, Hong Gyun Wu, Yeon Sil Kim, O. Kyu Noh, Jae Won Park, Dong Soo Lee, Jihae Lee, Young Suk Kim, Woo Yoon Park, Min Kyu Kang, Sunmi Jo, Yong Chan Ahn

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4 Scopus citations

Abstract

Purpose Lung Cancer Subcommittee of Korean Radiation Oncology Group (KROG) has recently launched a prospective clinical trial (KROG 17-06) of hippocampus-sparing whole brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in treating multiple brain metastases from non-small cell lung cancer. In order to improve trial quality, dummy run studies among the participating institutions were designed. This work reported the results of two-step dummy run procedures of the KROG 17-06 study. Materials and Methods Two steps tested hippocampus contouring variability and radiation therapy planning compliance. In the first step, the variation of the hippocampus delineation was investigated for two representative cases using the Dice similarity coefficients. In the second step, the participating institutions were requested to generate a HS-WBRT with SIB treatment plan for another representative case. The compliance of the treatment plans to the planning protocol was evaluated. Results In the first step, the median Dice similarity coefficients of the hippocampus contours for two other dummy run cases changed from 0.669 (range, 0.073 to 0.712) to 0.690 (range, 0.522 to 0.750) and from 0.291 (range, 0.219 to 0.522) to 0.412 (range, 0.264 to 0.598) after providing the hippocampus contouring feedback. In the second step, with providing additional plan priority and extended dose constraints to the target volumes and normal structures, we observed the improved compliance of the treatment plans to the planning protocol. Conclusion The dummy run studies demonstrated the notable inter-institutional variability in delineating the hippocampus and treatment plan generation, which could be decreased through feedback from the trial center.

Original languageEnglish
Pages (from-to)1001-1010
Number of pages10
JournalCancer Research and Treatment
Volume51
Issue number3
DOIs
StatePublished - 1 Jul 2019

Keywords

  • Dummy run
  • Hippocampus-sparing whole brain radiotherapy
  • Multi-institutional study
  • Non-small cell lung cancer
  • QA program

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