Effect of Bulnesia sarmienti ethanol extract on plasma levels of glucose and lipid in streptozotocin induced diabetic rats

Chang Ho Park, Dae Ik Kim, Eun Ji Shin, Gee Dong Lee, Jung Ok Kim, Kil Soo Kim, Joo Heon Hong

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study examined the effects of Bulnesia sarmienti ethanol extract on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Sprague Dawley rats were induced with diabetes mellitus by injecting STZ (45 mg/kg) into the tail vein, and were then divided into 5 groups: normal, STZ-control, and three experimental diabetic groups. The rats were fed a basal diet along with B. sarmienti ethanol extract for 8 weeks. According to the results, after 8 weeks of consuming the experimental diets, the body weights and food efficiency ratios of the B. sarmienti ethanol extract-fed groups were not different from those of the control group. However, the concentrations of plasma total-cholesterol, LDL-cholesterol, and triglycerides were significantly lower in the B. sarmienti ethanol extract groups as compared to those of the control group. Although a blood glucose control effect was not observed after the eight weeks of B. sarmienti ethanol extract treatment in this type-1 diabetes model, it was discovered that the experimental diets were highly effective at lowering levels of serum lipids, including triglycerides, total-cholesterol, and LDL-cholesterol.

Original languageEnglish
Pages (from-to)455-459
Number of pages5
JournalKorean Journal of Food Science and Technology
Volume40
Issue number4
StatePublished - 2008

Keywords

  • Bulnesia sarmienti
  • Cholesterol
  • Serum lipid
  • Streptozotocin
  • Triglyceride

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