Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

M. J. Park; K. S. Gwak; I. Yang; K. W. Kim; E. B. Jeung; J. W. Chang; I. G. Choi

doi:10.1016/j.fitote.2009.03.007

Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

M. J. Park
, K. S. Gwak
, I. Yang
, K. W. Kim
, E. B. Jeung
, J. W. Chang
, I. G. Choi

Department of Forest Ecology and Protection

Seoul National University
Chungbuk National University
Supeser Co. Ltd

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

Original language	English
Pages (from-to)	290-296
Number of pages	7
Journal	Fitoterapia
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.fitote.2009.03.007
State	Published - Jul 2009

Keywords

α-Terpineol
Citral
Electron microscopy
Eugenol
Nerolidol
Trichophyton mentagrophytes

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10.1016/j.fitote.2009.03.007

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title = "Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes",

abstract = "The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.",

keywords = "α-Terpineol, Citral, Electron microscopy, Eugenol, Nerolidol, Trichophyton mentagrophytes",

author = "Park, \{M. J.\} and Gwak, \{K. S.\} and I. Yang and Kim, \{K. W.\} and Jeung, \{E. B.\} and Chang, \{J. W.\} and Choi, \{I. G.\}",

year = "2009",

month = jul,

doi = "10.1016/j.fitote.2009.03.007",

language = "English",

volume = "80",

pages = "290--296",

journal = "Fitoterapia",

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TY - JOUR

T1 - Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

AU - Park, M. J.

AU - Gwak, K. S.

AU - Yang, I.

AU - Kim, K. W.

AU - Jeung, E. B.

AU - Chang, J. W.

AU - Choi, I. G.

PY - 2009/7

Y1 - 2009/7

N2 - The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

AB - The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

KW - α-Terpineol

KW - Citral

KW - Electron microscopy

KW - Eugenol

KW - Nerolidol

KW - Trichophyton mentagrophytes

UR - https://www.scopus.com/pages/publications/67349174190

U2 - 10.1016/j.fitote.2009.03.007

DO - 10.1016/j.fitote.2009.03.007

M3 - Article

C2 - 19345255

AN - SCOPUS:67349174190

SN - 0367-326X

VL - 80

SP - 290

EP - 296

JO - Fitoterapia

JF - Fitoterapia

IS - 5

ER -

Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

Abstract

Keywords

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