Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

M. J. Park; K. S. Gwak; I. Yang; K. W. Kim; E. B. Jeung; J. W. Chang; I. G. Choi

doi:10.1016/j.fitote.2009.03.007

Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

M. J. Park, K. S. Gwak, I. Yang, K. W. Kim, E. B. Jeung, J. W. Chang, I. G. Choi

Department of Forest Ecology and Protection

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

Original language	English
Pages (from-to)	290-296
Number of pages	7
Journal	Fitoterapia
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.fitote.2009.03.007
State	Published - Jul 2009

Keywords

α-Terpineol
Citral
Electron microscopy
Eugenol
Nerolidol
Trichophyton mentagrophytes

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10.1016/j.fitote.2009.03.007

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title = "Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes",

abstract = "The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.",

keywords = "α-Terpineol, Citral, Electron microscopy, Eugenol, Nerolidol, Trichophyton mentagrophytes",

author = "Park, \{M. J.\} and Gwak, \{K. S.\} and I. Yang and Kim, \{K. W.\} and Jeung, \{E. B.\} and Chang, \{J. W.\} and Choi, \{I. G.\}",

year = "2009",

month = jul,

doi = "10.1016/j.fitote.2009.03.007",

language = "English",

volume = "80",

pages = "290--296",

journal = "Fitoterapia",

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TY - JOUR

T1 - Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

AU - Park, M. J.

AU - Gwak, K. S.

AU - Yang, I.

AU - Kim, K. W.

AU - Jeung, E. B.

AU - Chang, J. W.

AU - Choi, I. G.

PY - 2009/7

Y1 - 2009/7

N2 - The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

AB - The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

KW - α-Terpineol

KW - Citral

KW - Electron microscopy

KW - Eugenol

KW - Nerolidol

KW - Trichophyton mentagrophytes

UR - https://www.scopus.com/pages/publications/67349174190

U2 - 10.1016/j.fitote.2009.03.007

DO - 10.1016/j.fitote.2009.03.007

M3 - Article

C2 - 19345255

AN - SCOPUS:67349174190

SN - 0367-326X

VL - 80

SP - 290

EP - 296

JO - Fitoterapia

JF - Fitoterapia

IS - 5

ER -

Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

Abstract

Keywords

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