Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Seung Soo Yoo; Jang Hyuck Lee; Mi Jeong Hong; Jin Eun Choi; Hyo Gyoung Kang; Sook Kyung Do; Ji Hyun Kim; Sun Ah Baek; Sun Ha Choi; Won Kee Lee; Yong Hoon Lee; Hyewon Seo; Jaehee Lee; Shin Yup Lee; Seung Ick Cha; Chang Ho Kim; Jae Yong Park

doi:10.1111/1759-7714.13566

Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Seung Soo Yoo, Jang Hyuck Lee, Mi Jeong Hong, Jin Eun Choi, Hyo Gyoung Kang, Sook Kyung Do, Ji Hyun Kim, Sun Ah Baek, Sun Ha Choi, Won Kee Lee, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Deltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10⁻⁴; hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10⁻⁷). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key points: Significant findings of the study: DTX1 rs1732786A > G was associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC) in our previous study. What this study adds: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).

Original language	English
Pages (from-to)	2698-2703
Number of pages	6
Journal	Thoracic Cancer
Volume	11
Issue number	9
DOIs	https://doi.org/10.1111/1759-7714.13566
State	Published - 1 Sep 2020

Keywords

DTX1
SCLC
response
rs1732786
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/1759-7714.13566

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Yoo, S. S., Lee, J. H., Hong, M. J., Choi, J. E., Kang, H. G., Do, S. K., Kim, J. H., Baek, S. A., Choi, S. H., Lee, W. K., Lee, Y. H., Seo, H., Lee, J., Lee, S. Y., Cha, S. I., Kim, C. H., & Park, J. Y. (2020). Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis. Thoracic Cancer, 11(9), 2698-2703. https://doi.org/10.1111/1759-7714.13566

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title = "Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis",

abstract = "Deltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10−4; hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10−7). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key points: Significant findings of the study: DTX1 rs1732786A > G was associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC) in our previous study. What this study adds: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).",

keywords = "DTX1, SCLC, response, rs1732786, survival",

author = "Yoo, {Seung Soo} and Lee, {Jang Hyuck} and Hong, {Mi Jeong} and Choi, {Jin Eun} and Kang, {Hyo Gyoung} and Do, {Sook Kyung} and Kim, {Ji Hyun} and Baek, {Sun Ah} and Choi, {Sun Ha} and Lee, {Won Kee} and Lee, {Yong Hoon} and Hyewon Seo and Jaehee Lee and Lee, {Shin Yup} and Cha, {Seung Ick} and Kim, {Chang Ho} and Park, {Jae Yong}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd",

year = "2020",

month = sep,

day = "1",

doi = "10.1111/1759-7714.13566",

language = "English",

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pages = "2698--2703",

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T1 - Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

AU - Yoo, Seung Soo

AU - Lee, Jang Hyuck

AU - Hong, Mi Jeong

AU - Choi, Jin Eun

AU - Kang, Hyo Gyoung

AU - Do, Sook Kyung

AU - Kim, Ji Hyun

AU - Baek, Sun Ah

AU - Choi, Sun Ha

AU - Lee, Won Kee

AU - Lee, Yong Hoon

AU - Seo, Hyewon

AU - Lee, Jaehee

AU - Lee, Shin Yup

AU - Cha, Seung Ick

AU - Kim, Chang Ho

AU - Park, Jae Yong

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Deltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10−4; hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10−7). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key points: Significant findings of the study: DTX1 rs1732786A > G was associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC) in our previous study. What this study adds: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).

AB - Deltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10−4; hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10−7). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key points: Significant findings of the study: DTX1 rs1732786A > G was associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC) in our previous study. What this study adds: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).

KW - DTX1

KW - SCLC

KW - response

KW - rs1732786

KW - survival

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SN - 1759-7706

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SP - 2698

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JO - Thoracic Cancer

JF - Thoracic Cancer

IS - 9

ER -

Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Abstract

Keywords

UN SDGs

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