Abstract
The influence of NK1 receptor antagonists applied iontophoretically on pulpal blood flow (PBF) was investigated. Along with substance P (SP, 0.8-20.0 ng/kg) administration to the canine pulp through the catheterized lingual artery, two NK1 receptor antagonists, [D-Pro2,D-Trp7,9]-SP and [D-Pro2,D-Phe7,D-Trp9]-SP (0.2-3.4 mM) were applied iontophoretically (cathodal current, 0.02-0.1 mA, 1 min) to the prepared class V dentinal cavity of ipsilateral teeth in 11 generally anesthetized cats. A paired t-test showed that SP administration caused significant increases of PBF (p < 0.05) without changing systemic blood pressure, and that SP and SP antagonist administration caused significantly less increase of PBF than in control of SP and 0.9% saline administration (p < 0.05). These data provide evidence that the iontophoretic application of NK1 receptor antagonists effectively attenuates SP-induced vasodilatation and show the possibility of their use in the control of neurogenic inflammation in the dental pulp.
Original language | English |
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Pages (from-to) | 647-651 |
Number of pages | 5 |
Journal | Journal of Endodontics |
Volume | 31 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2005 |
Keywords
- Iontophoresis
- NK1 receptor antagonist
- Pulpal blood flow
- Pulpal inflammation
- Substance P