Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation

Hwa Jin Park; Man Hee Rhee; Kyeong Mee Park; Ki Yeul Nam; Ki Hyun Park

doi:10.1016/0378-8741(95)01317-2

Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A₂ in human platelet aggregation

Hwa Jin Park, Man Hee Rhee, Kyeong Mee Park, Ki Yeul Nam, Ki Hyun Park

Department of Veterinary Medicine

Korea Ginseng and Tobacco Res. Inst.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The non-saponin fraction (NSF; lipophilic fraction) from the roots of Panax ginseng inhibited the aggregation of human platelets induced by thrombin (0.1 units/ml) in a dose-dependent manner. NSF induced the elevation of cGMP concentration in human platelets in a similar manner to molsidomine, a known vasodilator. NSF also inhibited Ca²⁺-influx into platelets. While verapamil, a Ca²⁺-antagonist, increased the cAMP level in platelets stimulated by thrombin, NSF had little effect on cAMP formation. Instead, NSF potently inhibited the thromboxane A₂ (TXA₂) production. The results suggest that NSF may regulate the levels of cGMP and TXA₂ to inhibit platelet aggregation induced by thrombin.

Original language	English
Pages (from-to)	157-162
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/0378-8741(95)01317-2
State	Published - 15 Dec 1995

Keywords

cAMP
cGMP
Panax ginseng
Platelet aggregation inhibition
Thromboxane A

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10.1016/0378-8741(95)01317-2

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title = "Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation",

abstract = "The non-saponin fraction (NSF; lipophilic fraction) from the roots of Panax ginseng inhibited the aggregation of human platelets induced by thrombin (0.1 units/ml) in a dose-dependent manner. NSF induced the elevation of cGMP concentration in human platelets in a similar manner to molsidomine, a known vasodilator. NSF also inhibited Ca2+-influx into platelets. While verapamil, a Ca2+-antagonist, increased the cAMP level in platelets stimulated by thrombin, NSF had little effect on cAMP formation. Instead, NSF potently inhibited the thromboxane A2 (TXA2) production. The results suggest that NSF may regulate the levels of cGMP and TXA2 to inhibit platelet aggregation induced by thrombin.",

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author = "Park, {Hwa Jin} and Rhee, {Man Hee} and Park, {Kyeong Mee} and Nam, {Ki Yeul} and Park, {Ki Hyun}",

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AU - Park, Hwa Jin

AU - Rhee, Man Hee

AU - Park, Kyeong Mee

AU - Nam, Ki Yeul

AU - Park, Ki Hyun

PY - 1995/12/15

Y1 - 1995/12/15

N2 - The non-saponin fraction (NSF; lipophilic fraction) from the roots of Panax ginseng inhibited the aggregation of human platelets induced by thrombin (0.1 units/ml) in a dose-dependent manner. NSF induced the elevation of cGMP concentration in human platelets in a similar manner to molsidomine, a known vasodilator. NSF also inhibited Ca2+-influx into platelets. While verapamil, a Ca2+-antagonist, increased the cAMP level in platelets stimulated by thrombin, NSF had little effect on cAMP formation. Instead, NSF potently inhibited the thromboxane A2 (TXA2) production. The results suggest that NSF may regulate the levels of cGMP and TXA2 to inhibit platelet aggregation induced by thrombin.

AB - The non-saponin fraction (NSF; lipophilic fraction) from the roots of Panax ginseng inhibited the aggregation of human platelets induced by thrombin (0.1 units/ml) in a dose-dependent manner. NSF induced the elevation of cGMP concentration in human platelets in a similar manner to molsidomine, a known vasodilator. NSF also inhibited Ca2+-influx into platelets. While verapamil, a Ca2+-antagonist, increased the cAMP level in platelets stimulated by thrombin, NSF had little effect on cAMP formation. Instead, NSF potently inhibited the thromboxane A2 (TXA2) production. The results suggest that NSF may regulate the levels of cGMP and TXA2 to inhibit platelet aggregation induced by thrombin.

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KW - cGMP

KW - Panax ginseng

KW - Platelet aggregation inhibition

KW - Thromboxane A

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Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A₂ in human platelet aggregation

Abstract

Keywords

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