Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs: A Retrospective Study

Naeun Hong; Ju Hyun An; Sung Soo Kim; Su Min Park; Ga Hyun Lim; Ye In Oh; Kyoung Won Seo; Hwa Young Youn

doi:10.3390/ani14111696

Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs: A Retrospective Study

Naeun Hong, Ju Hyun An, Sung Soo Kim, Su Min Park, Ga Hyun Lim, Ye In Oh, Kyoung Won Seo, Hwa Young Youn

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic kidney disease (CKD) commonly occurs in old dogs and cats. Oligo-fucoidan, fucoxanthin, and L-carnitine (OFL) compounds have a variety of reno-protective properties, including anti-inflammatory, anti-oxidative, and anti-fibrotic effects. Because their effects have not been investigated in naturally occurring canine CKD, we examined their reno-protective activities in dog patients with CKD. A total of 50 patients (OFL, n = 28; control, n = 22) were included in the analysis. A significant difference was identified in serum blood urea nitrogen and creatinine concentrations between the control and OFL groups at 6 months. No significant difference in electrolytes was found between the groups. A significant difference was identified in serum creatinine concentration between the control and OFL groups in azotemic (CKD IRIS stage 2–4) at 6 months. The OFL compounds showed a reno-protective effect, consistent with previous animal studies. The OFL combination can potentially delay the progression of canine CKD and be used as an adjuvant therapy.

Original language	English
Article number	1696
Journal	Animals
Volume	14
Issue number	11
DOIs	https://doi.org/10.3390/ani14111696
State	Published - Jun 2024

Keywords

L-carnitine
chronic kidney disease
fucoxanthin
oligo-fucoidan
reno-protective

Access to Document

10.3390/ani14111696

Cite this

@article{ac65a1aa69d24bfe820960b1bacd1f66,

title = "Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs: A Retrospective Study",

abstract = "Chronic kidney disease (CKD) commonly occurs in old dogs and cats. Oligo-fucoidan, fucoxanthin, and L-carnitine (OFL) compounds have a variety of reno-protective properties, including anti-inflammatory, anti-oxidative, and anti-fibrotic effects. Because their effects have not been investigated in naturally occurring canine CKD, we examined their reno-protective activities in dog patients with CKD. A total of 50 patients (OFL, n = 28; control, n = 22) were included in the analysis. A significant difference was identified in serum blood urea nitrogen and creatinine concentrations between the control and OFL groups at 6 months. No significant difference in electrolytes was found between the groups. A significant difference was identified in serum creatinine concentration between the control and OFL groups in azotemic (CKD IRIS stage 2–4) at 6 months. The OFL compounds showed a reno-protective effect, consistent with previous animal studies. The OFL combination can potentially delay the progression of canine CKD and be used as an adjuvant therapy.",

keywords = "L-carnitine, chronic kidney disease, fucoxanthin, oligo-fucoidan, reno-protective",

author = "Naeun Hong and An, {Ju Hyun} and Kim, {Sung Soo} and Park, {Su Min} and Lim, {Ga Hyun} and Oh, {Ye In} and Seo, {Kyoung Won} and Youn, {Hwa Young}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = jun,

doi = "10.3390/ani14111696",

language = "English",

volume = "14",

journal = "Animals",

issn = "2076-2615",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs

T2 - A Retrospective Study

AU - Hong, Naeun

AU - An, Ju Hyun

AU - Kim, Sung Soo

AU - Park, Su Min

AU - Lim, Ga Hyun

AU - Oh, Ye In

AU - Seo, Kyoung Won

AU - Youn, Hwa Young

PY - 2024/6

Y1 - 2024/6

N2 - Chronic kidney disease (CKD) commonly occurs in old dogs and cats. Oligo-fucoidan, fucoxanthin, and L-carnitine (OFL) compounds have a variety of reno-protective properties, including anti-inflammatory, anti-oxidative, and anti-fibrotic effects. Because their effects have not been investigated in naturally occurring canine CKD, we examined their reno-protective activities in dog patients with CKD. A total of 50 patients (OFL, n = 28; control, n = 22) were included in the analysis. A significant difference was identified in serum blood urea nitrogen and creatinine concentrations between the control and OFL groups at 6 months. No significant difference in electrolytes was found between the groups. A significant difference was identified in serum creatinine concentration between the control and OFL groups in azotemic (CKD IRIS stage 2–4) at 6 months. The OFL compounds showed a reno-protective effect, consistent with previous animal studies. The OFL combination can potentially delay the progression of canine CKD and be used as an adjuvant therapy.

AB - Chronic kidney disease (CKD) commonly occurs in old dogs and cats. Oligo-fucoidan, fucoxanthin, and L-carnitine (OFL) compounds have a variety of reno-protective properties, including anti-inflammatory, anti-oxidative, and anti-fibrotic effects. Because their effects have not been investigated in naturally occurring canine CKD, we examined their reno-protective activities in dog patients with CKD. A total of 50 patients (OFL, n = 28; control, n = 22) were included in the analysis. A significant difference was identified in serum blood urea nitrogen and creatinine concentrations between the control and OFL groups at 6 months. No significant difference in electrolytes was found between the groups. A significant difference was identified in serum creatinine concentration between the control and OFL groups in azotemic (CKD IRIS stage 2–4) at 6 months. The OFL compounds showed a reno-protective effect, consistent with previous animal studies. The OFL combination can potentially delay the progression of canine CKD and be used as an adjuvant therapy.

KW - L-carnitine

KW - chronic kidney disease

KW - fucoxanthin

KW - oligo-fucoidan

KW - reno-protective

UR - http://www.scopus.com/inward/record.url?scp=85195959953&partnerID=8YFLogxK

U2 - 10.3390/ani14111696

DO - 10.3390/ani14111696

M3 - Article

AN - SCOPUS:85195959953

SN - 2076-2615

VL - 14

JO - Animals

JF - Animals

IS - 11

M1 - 1696

ER -

Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs: A Retrospective Study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this