Effect of scaffolds with bone growth factors on new bone formation

Hae Ryong Song; Swee Hin Teoh; Jun Ho Wang; Hak Jun Kim; Ji Hoon Bae; Sung Eun Kim; Jerry Chan; Zhi Yong Zhang; Chang Wug Oh

doi:10.4032/9789814267861

Effect of scaffolds with bone growth factors on new bone formation

Hae Ryong Song, Swee Hin Teoh, Jun Ho Wang, Hak Jun Kim, Ji Hoon Bae, Sung Eun Kim, Jerry Chan, Zhi Yong Zhang, Chang Wug Oh

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Bone tissue engineering (BTE) using scaffolds with growth factors/ stem cells has received some success in clinical trails. Recently, osteogenic scaffolds using absorbable or nonabsorbable biomaterials have being investigated to repair bone defects. Scaffolds can provide the osteoconduction effect as well as a media to trap cells and allow them to proliferate and differentiate. Bioreactors provide a means to uniformly coat the scaffolds with cells and allow cells to proliferate better. Here we describe our work on preclinical animal trials applying the above concept to regenerate bone.

Original language	English
Title of host publication	Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine
Publisher	Pan Stanford Publishing Pte. Ltd.
Pages	871-901
Number of pages	31
ISBN (Print)	9789814267854
DOIs	https://doi.org/10.4032/9789814267861
State	Published - 31 Jan 2012

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10.4032/9789814267861

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AU - Song, Hae Ryong

AU - Teoh, Swee Hin

AU - Wang, Jun Ho

AU - Kim, Hak Jun

AU - Bae, Ji Hoon

AU - Kim, Sung Eun

AU - Chan, Jerry

AU - Zhang, Zhi Yong

AU - Oh, Chang Wug

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AB - Bone tissue engineering (BTE) using scaffolds with growth factors/ stem cells has received some success in clinical trails. Recently, osteogenic scaffolds using absorbable or nonabsorbable biomaterials have being investigated to repair bone defects. Scaffolds can provide the osteoconduction effect as well as a media to trap cells and allow them to proliferate and differentiate. Bioreactors provide a means to uniformly coat the scaffolds with cells and allow cells to proliferate better. Here we describe our work on preclinical animal trials applying the above concept to regenerate bone.

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PB - Pan Stanford Publishing Pte. Ltd.

ER -

Effect of scaffolds with bone growth factors on new bone formation

Abstract

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