Effect of silica content in PMMA/silica hybrids containing calcium salt on calcium phosphate formation and cell responses

Sang Hoon Rhee; Mi Hae Hwang; Je Yong Choi

Effect of silica content in PMMA/silica hybrids containing calcium salt on calcium phosphate formation and cell responses

Sang Hoon Rhee, Mi Hae Hwang, Je Yong Choi

Department of Medicine

Research output: Contribution to journal › Conference article › peer-review

5 Scopus citations

Abstract

The effect of silica content in the PMMA/silica hybrid on the calcium phosphate formation during the cell culture and their cell responses were investigated. The PMMA/silica hybrid containing calcium salt was prepared through a sol-gel method with varying the tetraethyl orthosilicate (TEOS) contents from 0 to 60 wt.%. As increasing the TEOS content in the hybrid, the Ca/P ratios of the calcium phosphate crystals formed during the cell culture decreased, while the attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts increased. All the cell responses showed maximum values at 40 wt.% TEOS content. It means that an appropriate silica content in the PMMA/silica hybrid is quite important for achieving better osteogenic property.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Key Engineering Materials
Volume	240-242
State	Published - 2003
Event	Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia Duration: 4 Dec 2002 → 8 Dec 2002

Keywords

Ca/P ratio
Calcium phosphate
Cell responses
PMMA
Silica

Cite this

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title = "Effect of silica content in PMMA/silica hybrids containing calcium salt on calcium phosphate formation and cell responses",

abstract = "The effect of silica content in the PMMA/silica hybrid on the calcium phosphate formation during the cell culture and their cell responses were investigated. The PMMA/silica hybrid containing calcium salt was prepared through a sol-gel method with varying the tetraethyl orthosilicate (TEOS) contents from 0 to 60 wt.%. As increasing the TEOS content in the hybrid, the Ca/P ratios of the calcium phosphate crystals formed during the cell culture decreased, while the attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts increased. All the cell responses showed maximum values at 40 wt.% TEOS content. It means that an appropriate silica content in the PMMA/silica hybrid is quite important for achieving better osteogenic property.",

keywords = "Ca/P ratio, Calcium phosphate, Cell responses, PMMA, Silica",

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year = "2003",

language = "English",

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pages = "183--186",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications Ltd.",

note = "Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 04-12-2002 Through 08-12-2002",

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TY - JOUR

T1 - Effect of silica content in PMMA/silica hybrids containing calcium salt on calcium phosphate formation and cell responses

AU - Rhee, Sang Hoon

AU - Hwang, Mi Hae

AU - Choi, Je Yong

PY - 2003

Y1 - 2003

N2 - The effect of silica content in the PMMA/silica hybrid on the calcium phosphate formation during the cell culture and their cell responses were investigated. The PMMA/silica hybrid containing calcium salt was prepared through a sol-gel method with varying the tetraethyl orthosilicate (TEOS) contents from 0 to 60 wt.%. As increasing the TEOS content in the hybrid, the Ca/P ratios of the calcium phosphate crystals formed during the cell culture decreased, while the attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts increased. All the cell responses showed maximum values at 40 wt.% TEOS content. It means that an appropriate silica content in the PMMA/silica hybrid is quite important for achieving better osteogenic property.

AB - The effect of silica content in the PMMA/silica hybrid on the calcium phosphate formation during the cell culture and their cell responses were investigated. The PMMA/silica hybrid containing calcium salt was prepared through a sol-gel method with varying the tetraethyl orthosilicate (TEOS) contents from 0 to 60 wt.%. As increasing the TEOS content in the hybrid, the Ca/P ratios of the calcium phosphate crystals formed during the cell culture decreased, while the attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts increased. All the cell responses showed maximum values at 40 wt.% TEOS content. It means that an appropriate silica content in the PMMA/silica hybrid is quite important for achieving better osteogenic property.

KW - Ca/P ratio

KW - Calcium phosphate

KW - Cell responses

KW - PMMA

KW - Silica

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M3 - Conference article

AN - SCOPUS:19244372050

SN - 1013-9826

VL - 240-242

SP - 183

EP - 186

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 4 December 2002 through 8 December 2002

ER -

Effect of silica content in PMMA/silica hybrids containing calcium salt on calcium phosphate formation and cell responses

Abstract

Keywords

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