Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils

Tae Cheon Kang; Sung Jin An; Seung Kook Park; In Koo Hwang; Soo Young Choi; Oh Shin Kwon; Moo Ho Won

doi:10.1016/S0304-3940(03)00072-7

Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils

Tae Cheon Kang, Sung Jin An, Seung Kook Park, In Koo Hwang, Soo Young Choi, Oh Shin Kwon, Moo Ho Won

Hallym University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Vigabatrin (VGB, γ-vinyl-γ-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons.

Original language	English
Pages (from-to)	115-118
Number of pages	4
Journal	Neuroscience Letters
Volume	340
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(03)00072-7
State	Published - 10 Apr 2003

Keywords

Epilepsy
Gerbil
Glutamate dehydrogenase
Hippocampus
Seizure
Vigabatrin

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10.1016/S0304-3940(03)00072-7

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title = "Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils",

abstract = "Vigabatrin (VGB, γ-vinyl-γ-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons.",

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author = "Kang, {Tae Cheon} and An, {Sung Jin} and Park, {Seung Kook} and Hwang, {In Koo} and Choi, {Soo Young} and Kwon, {Oh Shin} and Won, {Moo Ho}",

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T1 - Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils

AU - Kang, Tae Cheon

AU - An, Sung Jin

AU - Park, Seung Kook

AU - Hwang, In Koo

AU - Choi, Soo Young

AU - Kwon, Oh Shin

AU - Won, Moo Ho

PY - 2003/4/10

Y1 - 2003/4/10

N2 - Vigabatrin (VGB, γ-vinyl-γ-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons.

AB - Vigabatrin (VGB, γ-vinyl-γ-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons.

KW - Epilepsy

KW - Gerbil

KW - Glutamate dehydrogenase

KW - Hippocampus

KW - Seizure

KW - Vigabatrin

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U2 - 10.1016/S0304-3940(03)00072-7

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils

Abstract

Keywords

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