Effects of Allopurinol and Apocynin on Renal Ischemia-Reperfusion Injury in Rats

E. K. Choi, H. Jung, K. H. Kwak, J. Yeo, S. J. Yi, C. Y. Park, T. H. Ryu, Y. H. Jeon, K. M. Park, D. G. Lim

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22 Scopus citations


Background This study evaluated the effects of allopurinol (ALP), a xanthine oxidase inhibitor, and apocynin (APC), a NADPH oxidase inhibitor, administered alone or together, on kidney damage caused by renal ischemia-reperfusion (IR) in rats. Methods Thirty rats were randomly assigned to 5 groups. Group 1 was a sham group. Group 2 was the renal IR control group (30-min ischemia followed by 24-h reperfusion). In groups 3 and 4, ALP or APC, respectively, was administered 1 h before the ischemia. In group 5, ALP and APC were co-administered. Blood urea nitrogen (BUN) and serum creatinine (Cr), renal tissue malondialdehyde (MDA) and superoxide dismutase (SOD), and histological changes were evaluated. Results A significant increase in BUN and Cr level, and histological damage was seen in the IR control group, indicating renal injury. Elevated MDA and decreased SOD levels in the IR control group demonstrated that renal damage occurred through oxidative stress. Pretreatment with ALP or APC alone or together prevented IR-induced renal damage. However, there was no significant difference between treatment with a single drug and co-administration of ALP and APC. Conclusions The use of ALP and/or APC before ischemia may be beneficial to ameliorate renal IR injury.

Original languageEnglish
Pages (from-to)1633-1638
Number of pages6
JournalTransplantation Proceedings
Issue number6
StatePublished - 1 Jul 2015


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