Abstract
The Artemisia capillaris THUNB is a perennial herb that belongs to the family Compositae spp. and probably the most common plant among the various herbal folk remedies being used in the treatment of abdominal pain, hepatitis, chronic liver disease, jaundice and coughing in Korea. This experiment was conducted to investigate the effects of Artemisia capillaris extracts on the amounts of splenocytes-derived cytokine (TNF-α, IL-1β and IL-10). In in vivo experimental tests using 210 ICR mice with Hepa-1c1c7 or sarcoma 180 cancer line, splenocytes derived cytokine contents were significantly (p<0.05) reduced in the Hepa-1c1c7 and Sarcoma 180 inoculated vehicle controls, HP and SP, compared to those of the intact vehicle control on both the 28th day and the 42nd day, respectively. However, these decreases of TNF-α, IL-1β and IL-10 levels induced by tumor inoculations were significantly (p < 0.01, p < 0.05) inhibited by mACH (Artemisia capillaris methanol extracts) treatment regardless of the type of experiments and tumor cells inoculated. The results suggest that Artemisia capillaris methanol extracts have prominent anti-inflammation effects on the cancer cell lines Hepa-1c1c7 and Sarcoma 180.
Original language | English |
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Pages (from-to) | 408-412 |
Number of pages | 5 |
Journal | Journal of Veterinary Clinics |
Volume | 26 |
Issue number | 5 |
State | Published - 2009 |
Keywords
- Anti-inflammation effect
- Artemisia capillaris
- Cytokine (TNF-αIL-1β and IL-10)
- Extract
- Splenocytes