Effects of Artemisia capillaris methanol extract on the amounts of splenocytes-derived cytokines in tumor cells inoculated mice

Hong Tae Kim, Sae Kwang Ku, Ju Wan Kim, Tae Won Jin, Sung Wook Koo, Mee Kyung Lim, Yoon Jung Do, Kwang Ho Jang, Tae Ho Oh, Keun Woo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

The Artemisia capillaris THUNB is a perennial herb that belongs to the family Compositae spp. and probably the most common plant among the various herbal folk remedies being used in the treatment of abdominal pain, hepatitis, chronic liver disease, jaundice and coughing in Korea. This experiment was conducted to investigate the effects of Artemisia capillaris extracts on the amounts of splenocytes-derived cytokine (TNF-α, IL-1β and IL-10). In in vivo experimental tests using 210 ICR mice with Hepa-1c1c7 or sarcoma 180 cancer line, splenocytes derived cytokine contents were significantly (p<0.05) reduced in the Hepa-1c1c7 and Sarcoma 180 inoculated vehicle controls, HP and SP, compared to those of the intact vehicle control on both the 28th day and the 42nd day, respectively. However, these decreases of TNF-α, IL-1β and IL-10 levels induced by tumor inoculations were significantly (p < 0.01, p < 0.05) inhibited by mACH (Artemisia capillaris methanol extracts) treatment regardless of the type of experiments and tumor cells inoculated. The results suggest that Artemisia capillaris methanol extracts have prominent anti-inflammation effects on the cancer cell lines Hepa-1c1c7 and Sarcoma 180.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
JournalJournal of Veterinary Clinics
Volume26
Issue number5
StatePublished - 2009

Keywords

  • Anti-inflammation effect
  • Artemisia capillaris
  • Cytokine (TNF-αIL-1β and IL-10)
  • Extract
  • Splenocytes

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