Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

Chang Kiu Moon; Jin Ho Chung; You Mie Lee; Soo Hwan Lee; Gwi Seo Hwang; Kwang Sik Park; Myung Soo Mock; Seong Gon Kim; Young Soo Ahn; Jeong Hee Ann

doi:10.1007/BF02857719

Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

Chang Kiu Moon, Jin Ho Chung, You Mie Lee, Soo Hwan Lee, Gwi Seo Hwang, Kwang Sik Park, Myung Soo Mock, Seong Gon Kim, Young Soo Ahn, Jeong Hee Ann

Seoul National University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Impaired erythrocyte deformability was considered to play an important role in microcirculatory disturbances. We recently confirmed that brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2,3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with brazilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2,3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.

Original language	English
Pages (from-to)	149-154
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/BF02857719
State	Published - Jun 1988

Keywords

2,3-diphosphoglycerate
ATP
brazilin
calcium
erythrocyte deformability
streptozotocin-induced diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02857719

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title = "Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats",

abstract = "Impaired erythrocyte deformability was considered to play an important role in microcirculatory disturbances. We recently confirmed that brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2,3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with brazilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2,3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.",

keywords = "2,3-diphosphoglycerate, ATP, brazilin, calcium, erythrocyte deformability, streptozotocin-induced diabetes",

author = "Moon, {Chang Kiu} and Chung, {Jin Ho} and Lee, {You Mie} and Lee, {Soo Hwan} and Hwang, {Gwi Seo} and Park, {Kwang Sik} and Mock, {Myung Soo} and Kim, {Seong Gon} and Ahn, {Young Soo} and Ann, {Jeong Hee}",

year = "1988",

month = jun,

doi = "10.1007/BF02857719",

language = "English",

volume = "11",

pages = "149--154",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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TY - JOUR

T1 - Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

AU - Moon, Chang Kiu

AU - Chung, Jin Ho

AU - Lee, You Mie

AU - Lee, Soo Hwan

AU - Hwang, Gwi Seo

AU - Park, Kwang Sik

AU - Mock, Myung Soo

AU - Kim, Seong Gon

AU - Ahn, Young Soo

AU - Ann, Jeong Hee

PY - 1988/6

Y1 - 1988/6

N2 - Impaired erythrocyte deformability was considered to play an important role in microcirculatory disturbances. We recently confirmed that brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2,3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with brazilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2,3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.

AB - Impaired erythrocyte deformability was considered to play an important role in microcirculatory disturbances. We recently confirmed that brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2,3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with brazilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2,3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.

KW - 2,3-diphosphoglycerate

KW - ATP

KW - brazilin

KW - calcium

KW - erythrocyte deformability

KW - streptozotocin-induced diabetes

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U2 - 10.1007/BF02857719

DO - 10.1007/BF02857719

M3 - Article

AN - SCOPUS:0012254853

SN - 0253-6269

VL - 11

SP - 149

EP - 154

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 2

ER -

Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

Abstract

Keywords

UN SDGs

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