Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway

Ha Yeong Kang; Tran The Bach; Sang Mi Eum; Sung Keun Jung

doi:10.9721/KJFST.2022.54.6.587

Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway

Ha Yeong Kang, Tran The Bach, Sang Mi Eum, Sung Keun Jung

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We evaluated the anti-inflammatory effects of Causonis japonica (Thunb.) Raf. extract (CJE) in mouse RAW264.7 macrophage cells. The CJE significantly suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production. It also suppressed LPS-induced phosphorylation of IkB kinase (IKK), p65, the translocation of p65 from the cytosol to the nucleus, and the phosphorylation of mitogen-activated protein kinases (MAPKs). Overall, our results suggested that the CJE suppresses LPS-induced inflammatory responses by regulating the NF-κB and MAPK signaling pathways.

Original language	English
Pages (from-to)	587-593
Number of pages	7
Journal	Korean Journal of Food Science and Technology
Volume	54
Issue number	6
DOIs	https://doi.org/10.9721/KJFST.2022.54.6.587
State	Published - Dec 2022

Keywords

anti-inflammatory effect
Causonis japonica (Thunb.) Raf. extract (CJE)
mitogen-activated protein kinase (MAPK)
NF-κB (nuclear factor kappa-B)
nitric oxide (NO)

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10.9721/KJFST.2022.54.6.587

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title = "Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway",

abstract = "We evaluated the anti-inflammatory effects of Causonis japonica (Thunb.) Raf. extract (CJE) in mouse RAW264.7 macrophage cells. The CJE significantly suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production. It also suppressed LPS-induced phosphorylation of IkB kinase (IKK), p65, the translocation of p65 from the cytosol to the nucleus, and the phosphorylation of mitogen-activated protein kinases (MAPKs). Overall, our results suggested that the CJE suppresses LPS-induced inflammatory responses by regulating the NF-κB and MAPK signaling pathways.",

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author = "Kang, {Ha Yeong} and Bach, {Tran The} and Eum, {Sang Mi} and Jung, {Sung Keun}",

year = "2022",

month = dec,

doi = "10.9721/KJFST.2022.54.6.587",

language = "English",

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T1 - Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway

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AU - Bach, Tran The

AU - Eum, Sang Mi

AU - Jung, Sung Keun

PY - 2022/12

Y1 - 2022/12

N2 - We evaluated the anti-inflammatory effects of Causonis japonica (Thunb.) Raf. extract (CJE) in mouse RAW264.7 macrophage cells. The CJE significantly suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production. It also suppressed LPS-induced phosphorylation of IkB kinase (IKK), p65, the translocation of p65 from the cytosol to the nucleus, and the phosphorylation of mitogen-activated protein kinases (MAPKs). Overall, our results suggested that the CJE suppresses LPS-induced inflammatory responses by regulating the NF-κB and MAPK signaling pathways.

AB - We evaluated the anti-inflammatory effects of Causonis japonica (Thunb.) Raf. extract (CJE) in mouse RAW264.7 macrophage cells. The CJE significantly suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production. It also suppressed LPS-induced phosphorylation of IkB kinase (IKK), p65, the translocation of p65 from the cytosol to the nucleus, and the phosphorylation of mitogen-activated protein kinases (MAPKs). Overall, our results suggested that the CJE suppresses LPS-induced inflammatory responses by regulating the NF-κB and MAPK signaling pathways.

KW - anti-inflammatory effect

KW - Causonis japonica (Thunb.) Raf. extract (CJE)

KW - mitogen-activated protein kinase (MAPK)

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Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway

Abstract

Keywords

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