TY - JOUR
T1 - Effects of Methylsulfonylmethane on UVB-induced Skin Damage
T2 - An Experimental Study in a Mouse Model
AU - Chu, Seung Gyun
AU - Chang, Yong June
AU - Ryu, Jeong Yeop
AU - Lee, Joon Seok
AU - Choi, Kang Young
AU - Chung, Ho Yun
AU - Cho, Byung Chae
AU - Yang, Jung Dug
N1 - Publisher Copyright:
© 2022 International Institute of Anticancer Research. All rights reserved.
PY - 2022/11
Y1 - 2022/11
N2 - Background/Aim: The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used. Patients and Methods: Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM. Results: After the end of the experiment, the wrinkle score was 0.4, 2.5, 1.8, 1.5 for Groups A, B, C, and D, respectively. Epidermal thickness was 40 μm, 70 μm, 60 μm, 55 μm in Groups A, B, C, and D, respectively. Group C showed less collagen confirmation loss and more angiogenesis and elastin precursor production. Elastic fiber linearity was 0.901±0.02, 0.551±0.04, 0.751±0.04, 0.822±0.03 for Groups A, B, C, and D, respectively. Conclusion: Injection of MSM in mice subjected to UVB-induced skin damage reduces the wrinkle score and protects against photoaging.
AB - Background/Aim: The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used. Patients and Methods: Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM. Results: After the end of the experiment, the wrinkle score was 0.4, 2.5, 1.8, 1.5 for Groups A, B, C, and D, respectively. Epidermal thickness was 40 μm, 70 μm, 60 μm, 55 μm in Groups A, B, C, and D, respectively. Group C showed less collagen confirmation loss and more angiogenesis and elastin precursor production. Elastic fiber linearity was 0.901±0.02, 0.551±0.04, 0.751±0.04, 0.822±0.03 for Groups A, B, C, and D, respectively. Conclusion: Injection of MSM in mice subjected to UVB-induced skin damage reduces the wrinkle score and protects against photoaging.
KW - antiaging
KW - Methylsulfonylmethane
KW - retinoic acid
KW - UVB
UR - http://www.scopus.com/inward/record.url?scp=85141004392&partnerID=8YFLogxK
U2 - 10.21873/invivo.13007
DO - 10.21873/invivo.13007
M3 - Article
C2 - 36309396
AN - SCOPUS:85141004392
SN - 0258-851X
VL - 36
SP - 2714
EP - 2721
JO - In Vivo
JF - In Vivo
IS - 6
ER -
