Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production

Sang Yong Kim; Sang Hyun Kim; Hye Young Shin; Jong Pil Lim; Byeong Suk Chae; Jeong Suk Park; Seong Gyun Hong; Myung Soo Kim; Dong Gwang Jo; Won Hwan Park; Tae Yong Shin

Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production

Sang Yong Kim, Sang Hyun Kim, Hye Young Shin, Jong Pil Lim, Byeong Suk Chae, Jeong Suk Park, Seong Gyun Hong, Myung Soo Kim, Dong Gwang Jo, Won Hwan Park, Tae Yong Shin

Department of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In this study, we investigated the effect of aqueous extract of Prunella vulgaris (Labiatae; PVAE) on the mast cell-mediated allergy model. We found that PVAE (0.001-0.1 g/kg) dose dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. PVAE decreased the IgE-mediated local allergic reaction, passive cutaneous anaphylaxis. In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6, and IL-8 secretion in human mast cells. The inhibitory effect of PVAE on proinflammatory cytokines was nuclear factor-κB (NF-κB) dependent. PVAE suppressed PMA and A23187-induced NF-κB/DNA binding activity and NF-κB-dependent gene reporter assay. Our findings provide evidence that PVAE inhibits mast cell-derived immediate-type allergic reactions and involvement of proinflammatory cytokines and NF-κB in these effects.

Original language	English
Pages (from-to)	921-926
Number of pages	6
Journal	Experimental Biology and Medicine
Volume	232
Issue number	7
State	Published - Jul 2007

Keywords

Anaphylaxis
Inflammatory cytokine
Mast cells
Nuclear factor-κB
Prunella vulgaris

Cite this

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title = "Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production",

abstract = "In this study, we investigated the effect of aqueous extract of Prunella vulgaris (Labiatae; PVAE) on the mast cell-mediated allergy model. We found that PVAE (0.001-0.1 g/kg) dose dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. PVAE decreased the IgE-mediated local allergic reaction, passive cutaneous anaphylaxis. In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6, and IL-8 secretion in human mast cells. The inhibitory effect of PVAE on proinflammatory cytokines was nuclear factor-κB (NF-κB) dependent. PVAE suppressed PMA and A23187-induced NF-κB/DNA binding activity and NF-κB-dependent gene reporter assay. Our findings provide evidence that PVAE inhibits mast cell-derived immediate-type allergic reactions and involvement of proinflammatory cytokines and NF-κB in these effects.",

keywords = "Anaphylaxis, Inflammatory cytokine, Mast cells, Nuclear factor-κB, Prunella vulgaris",

author = "Kim, {Sang Yong} and Kim, {Sang Hyun} and Shin, {Hye Young} and Lim, {Jong Pil} and Chae, {Byeong Suk} and Park, {Jeong Suk} and Hong, {Seong Gyun} and Kim, {Myung Soo} and Jo, {Dong Gwang} and Park, {Won Hwan} and Shin, {Tae Yong}",

year = "2007",

month = jul,

language = "English",

volume = "232",

pages = "921--926",

journal = "Experimental Biology and Medicine",

issn = "1535-3702",

publisher = "SAGE Publications Inc.",

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AU - Kim, Sang Yong

AU - Kim, Sang Hyun

AU - Shin, Hye Young

AU - Lim, Jong Pil

AU - Chae, Byeong Suk

AU - Park, Jeong Suk

AU - Hong, Seong Gyun

AU - Kim, Myung Soo

AU - Jo, Dong Gwang

AU - Park, Won Hwan

AU - Shin, Tae Yong

PY - 2007/7

Y1 - 2007/7

N2 - In this study, we investigated the effect of aqueous extract of Prunella vulgaris (Labiatae; PVAE) on the mast cell-mediated allergy model. We found that PVAE (0.001-0.1 g/kg) dose dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. PVAE decreased the IgE-mediated local allergic reaction, passive cutaneous anaphylaxis. In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6, and IL-8 secretion in human mast cells. The inhibitory effect of PVAE on proinflammatory cytokines was nuclear factor-κB (NF-κB) dependent. PVAE suppressed PMA and A23187-induced NF-κB/DNA binding activity and NF-κB-dependent gene reporter assay. Our findings provide evidence that PVAE inhibits mast cell-derived immediate-type allergic reactions and involvement of proinflammatory cytokines and NF-κB in these effects.

AB - In this study, we investigated the effect of aqueous extract of Prunella vulgaris (Labiatae; PVAE) on the mast cell-mediated allergy model. We found that PVAE (0.001-0.1 g/kg) dose dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. PVAE decreased the IgE-mediated local allergic reaction, passive cutaneous anaphylaxis. In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6, and IL-8 secretion in human mast cells. The inhibitory effect of PVAE on proinflammatory cytokines was nuclear factor-κB (NF-κB) dependent. PVAE suppressed PMA and A23187-induced NF-κB/DNA binding activity and NF-κB-dependent gene reporter assay. Our findings provide evidence that PVAE inhibits mast cell-derived immediate-type allergic reactions and involvement of proinflammatory cytokines and NF-κB in these effects.

KW - Anaphylaxis

KW - Inflammatory cytokine

KW - Mast cells

KW - Nuclear factor-κB

KW - Prunella vulgaris

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M3 - Article

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AN - SCOPUS:34347401615

SN - 1535-3702

VL - 232

SP - 921

EP - 926

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 7

ER -

Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production

Abstract

Keywords

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