Effects of total body irradiation-based conditioning on allogeneic stem cell transplantation for pediatric acute leukemia: A single-institution study

Jongmoo Park, Eun Kyung Choi, Jong Hoon Kim, Sang Wook Lee, Si Yeol Song, Sang Min Yoon, Young Seok Kim, Su Ssan Kim, Jin Hong Park, Jaehyeon Park, Seung Do Ahn

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients. Materials and Methods: From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic leukemia (ALL, 75%) and 7 were diagnosed with acute myeloid leukemia (AML, 25%). TBI was completed 4 days or 1 day before stem cell infusion. Patients underwent radiation therapy with bilateral parallel opposing fields and 6-MV X-rays. The Kaplan-Meier method was used to calculate survival outcomes. Results: The 2-year event-free survival and overall survival rates were 66% and 56%, respectively (71.4% and 60.0% in AML patients vs. 64.3% and 52.4% in ALL patients, respectively). Treatment related mortality rate were 25%. Acute and chronic graft-versus-host disease was a major complication; other complications included endocrine dysfunction and pulmonary complications. Common complications from TBI were nausea (89%) and cataracts (7.1%). Conclusion: The efficacy and toxicity data in this study of TBI-based conditioning to pediatric acute leukemia patients were comparable with previous studies. However, clinicians need to focus on the acute and chronic complications related to allo-SCT.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalRadiation Oncology Journal
Volume32
Issue number3
DOIs
StatePublished - 1 Sep 2014

Keywords

  • Acute lymphoid leukemia
  • Acute myeloid leukemia
  • Child
  • Stem cell transplantation
  • Total body irradiation

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