Efficient radiolabeling of rutin with 125I and biodistribution study of radiolabeled rutin

Mi Hee Choi; Jong Kook Rho; Jung Ae Kang; Ha Eun Shim; You Ree Nam; Seonhye Yoon; Hye Rim Kim; Dae Seong Choi; Sang Hyun Park; Beom Su Jang; Jongho Jeon

doi:10.1007/s10967-015-4415-8

Efficient radiolabeling of rutin with ¹²⁵I and biodistribution study of radiolabeled rutin

Mi Hee Choi, Jong Kook Rho, Jung Ae Kang, Ha Eun Shim, You Ree Nam, Seonhye Yoon, Hye Rim Kim, Dae Seong Choi, Sang Hyun Park, Beom Su Jang, Jongho Jeon

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided ¹²⁵I-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered ¹²⁵I-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected ¹²⁵I-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin.

Original language	English
Pages (from-to)	477-483
Number of pages	7
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	308
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-4415-8
State	Published - 1 May 2016

Keywords

I
Biodistribution
Radiolabeling
Rutin
SPECT/CT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-015-4415-8

Cite this

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title = "Efficient radiolabeling of rutin with 125I and biodistribution study of radiolabeled rutin",

abstract = "The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided 125I-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered 125I-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected 125I-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin.",

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AU - Choi, Mi Hee

AU - Rho, Jong Kook

AU - Kang, Jung Ae

AU - Shim, Ha Eun

AU - Nam, You Ree

AU - Yoon, Seonhye

AU - Kim, Hye Rim

AU - Choi, Dae Seong

AU - Park, Sang Hyun

AU - Jang, Beom Su

AU - Jeon, Jongho

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AB - The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided 125I-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered 125I-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected 125I-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin.

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