Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases

Aaron M. Leconte; Shigeo Matsuda; Gil Tae Hwang; Floyd E. Romesberg

doi:10.1002/anie.200601272

Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases

Aaron M. Leconte, Shigeo Matsuda, Gil Tae Hwang, Floyd E. Romesberg

Scripps Research Institute

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

(Figure Presented) Getting on with it: A common problem with hydrophobic non-natural base pairs - the inefficient extension following such a base pair - is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem of non-natural bases: mispairs with deoxyadenosine.

Original language	English
Pages (from-to)	4326-4329
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	26
DOIs	https://doi.org/10.1002/anie.200601272
State	Published - 26 Jun 2006

Keywords

DNA replication
Genetic alphabet
Hydrophobic effect
Nucleobases
Pyridones

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10.1002/anie.200601272

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title = "Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases",

abstract = "(Figure Presented) Getting on with it: A common problem with hydrophobic non-natural base pairs - the inefficient extension following such a base pair - is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem of non-natural bases: mispairs with deoxyadenosine.",

keywords = "DNA replication, Genetic alphabet, Hydrophobic effect, Nucleobases, Pyridones",

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AU - Matsuda, Shigeo

AU - Hwang, Gil Tae

AU - Romesberg, Floyd E.

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AB - (Figure Presented) Getting on with it: A common problem with hydrophobic non-natural base pairs - the inefficient extension following such a base pair - is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem of non-natural bases: mispairs with deoxyadenosine.

KW - DNA replication

KW - Genetic alphabet

KW - Hydrophobic effect

KW - Nucleobases

KW - Pyridones

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ER -

Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases

Abstract

Keywords

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