Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital

Mamata Gurung; Jae Su Rho; Yoo Chul Lee; Hyung Sun Kim; Sun Young Moon; Byung Hyuk Yu; Joo Hyung Lee; Cheol Woo Jang; Seung Yeon Chung; Il Hwan Cho; Hyeon Sook Jee; Seung Won Choi; Ji Young Heo; Je Chul Lee

doi:10.1016/j.meegid.2013.07.016

Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital

Mamata Gurung, Jae Su Rho, Yoo Chul Lee, Hyung Sun Kim, Sun Young Moon, Byung Hyuk Yu, Joo Hyung Lee, Cheol Woo Jang, Seung Yeon Chung, Il Hwan Cho, Hyeon Sook Jee, Seung Won Choi, Ji Young Heo, Je Chul Lee

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii (CRAB) clones cause a serious therapeutic problem. This study was aimed to investigate the clonal diversity and genetic basis of antimicrobial resistance among the 69 CRAB isolates from 2009 to 2010 in a Korean hospital. All CRAB isolates were found to be sequence type (ST) 2 using the Institute Pasteur's multilocus sequence typing (MLST) scheme, but classified into two sequence groups and nine pulsotypes. Fifty-six CRAB isolates belonging to two main pulsotypes were found to be ST191 using the Bartual's MLST scheme. All CRAB isolates showed an extensively drug-resistant phenotype. The bla_OXA-51/bla_OXA-23, bla_AmpC/bla_PER-1 and armA genes were largely responsible for resistance to carbapenems, extended-spectrum β-lactams and aminoglycosides, respectively. The first CRAB strains identified in 2005 in this hospital were found to be ST2 using the Institute Pasteur's MLST scheme, but showed ST353 using the Bartual's MLST scheme and different pulsotypes from the CRAB isolates from 2009 to 2010. In conclusion, this is the first report of emergence and spread of A. baumannii ST191 in Korea, as well of the genetic basis of its antimicrobial resistance.

Original language	English
Pages (from-to)	219-222
Number of pages	4
Journal	Infection, Genetics and Evolution
Volume	19
DOIs	https://doi.org/10.1016/j.meegid.2013.07.016
State	Published - Oct 2013

Keywords

Carbapenem
Clonal spread
Extended-spectrum β-lactamase
Multi-drug resistance
Sequence type

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.meegid.2013.07.016

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Gurung, M., Rho, J. S., Lee, Y. C., Kim, H. S., Moon, S. Y., Yu, B. H., Lee, J. H., Jang, C. W., Chung, S. Y., Cho, I. H., Jee, H. S., Choi, S. W., Heo, J. Y., & Lee, J. C. (2013). Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital. Infection, Genetics and Evolution, 19, 219-222. https://doi.org/10.1016/j.meegid.2013.07.016

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title = "Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital",

abstract = "Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii (CRAB) clones cause a serious therapeutic problem. This study was aimed to investigate the clonal diversity and genetic basis of antimicrobial resistance among the 69 CRAB isolates from 2009 to 2010 in a Korean hospital. All CRAB isolates were found to be sequence type (ST) 2 using the Institute Pasteur's multilocus sequence typing (MLST) scheme, but classified into two sequence groups and nine pulsotypes. Fifty-six CRAB isolates belonging to two main pulsotypes were found to be ST191 using the Bartual's MLST scheme. All CRAB isolates showed an extensively drug-resistant phenotype. The blaOXA-51/blaOXA-23, blaAmpC/blaPER-1 and armA genes were largely responsible for resistance to carbapenems, extended-spectrum β-lactams and aminoglycosides, respectively. The first CRAB strains identified in 2005 in this hospital were found to be ST2 using the Institute Pasteur's MLST scheme, but showed ST353 using the Bartual's MLST scheme and different pulsotypes from the CRAB isolates from 2009 to 2010. In conclusion, this is the first report of emergence and spread of A. baumannii ST191 in Korea, as well of the genetic basis of its antimicrobial resistance.",

keywords = "Carbapenem, Clonal spread, Extended-spectrum β-lactamase, Multi-drug resistance, Sequence type",

author = "Mamata Gurung and Rho, {Jae Su} and Lee, {Yoo Chul} and Kim, {Hyung Sun} and Moon, {Sun Young} and Yu, {Byung Hyuk} and Lee, {Joo Hyung} and Jang, {Cheol Woo} and Chung, {Seung Yeon} and Cho, {Il Hwan} and Jee, {Hyeon Sook} and Choi, {Seung Won} and Heo, {Ji Young} and Lee, {Je Chul}",

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doi = "10.1016/j.meegid.2013.07.016",

language = "English",

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T1 - Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital

AU - Gurung, Mamata

AU - Rho, Jae Su

AU - Lee, Yoo Chul

AU - Kim, Hyung Sun

AU - Moon, Sun Young

AU - Yu, Byung Hyuk

AU - Lee, Joo Hyung

AU - Jang, Cheol Woo

AU - Chung, Seung Yeon

AU - Cho, Il Hwan

AU - Jee, Hyeon Sook

AU - Choi, Seung Won

AU - Heo, Ji Young

AU - Lee, Je Chul

PY - 2013/10

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N2 - Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii (CRAB) clones cause a serious therapeutic problem. This study was aimed to investigate the clonal diversity and genetic basis of antimicrobial resistance among the 69 CRAB isolates from 2009 to 2010 in a Korean hospital. All CRAB isolates were found to be sequence type (ST) 2 using the Institute Pasteur's multilocus sequence typing (MLST) scheme, but classified into two sequence groups and nine pulsotypes. Fifty-six CRAB isolates belonging to two main pulsotypes were found to be ST191 using the Bartual's MLST scheme. All CRAB isolates showed an extensively drug-resistant phenotype. The blaOXA-51/blaOXA-23, blaAmpC/blaPER-1 and armA genes were largely responsible for resistance to carbapenems, extended-spectrum β-lactams and aminoglycosides, respectively. The first CRAB strains identified in 2005 in this hospital were found to be ST2 using the Institute Pasteur's MLST scheme, but showed ST353 using the Bartual's MLST scheme and different pulsotypes from the CRAB isolates from 2009 to 2010. In conclusion, this is the first report of emergence and spread of A. baumannii ST191 in Korea, as well of the genetic basis of its antimicrobial resistance.

AB - Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii (CRAB) clones cause a serious therapeutic problem. This study was aimed to investigate the clonal diversity and genetic basis of antimicrobial resistance among the 69 CRAB isolates from 2009 to 2010 in a Korean hospital. All CRAB isolates were found to be sequence type (ST) 2 using the Institute Pasteur's multilocus sequence typing (MLST) scheme, but classified into two sequence groups and nine pulsotypes. Fifty-six CRAB isolates belonging to two main pulsotypes were found to be ST191 using the Bartual's MLST scheme. All CRAB isolates showed an extensively drug-resistant phenotype. The blaOXA-51/blaOXA-23, blaAmpC/blaPER-1 and armA genes were largely responsible for resistance to carbapenems, extended-spectrum β-lactams and aminoglycosides, respectively. The first CRAB strains identified in 2005 in this hospital were found to be ST2 using the Institute Pasteur's MLST scheme, but showed ST353 using the Bartual's MLST scheme and different pulsotypes from the CRAB isolates from 2009 to 2010. In conclusion, this is the first report of emergence and spread of A. baumannii ST191 in Korea, as well of the genetic basis of its antimicrobial resistance.

KW - Carbapenem

KW - Clonal spread

KW - Extended-spectrum β-lactamase

KW - Multi-drug resistance

KW - Sequence type

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SN - 1567-1348

VL - 19

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JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

Emergence and spread of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital

Abstract

Keywords

UN SDGs

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