Enantioseparation of racemic 1,1′-binaphthyl-2,2′-diamine by preparative liquid chromatography

Jae Jeong Ryoo, Woo Jeong Kwon, Tae Hyuk Kim, Kwang Pill Lee, Seong Ho Choi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved Chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1′-binaphthyl-2,2′-diamine (4).

Original languageEnglish
Pages (from-to)1336-1340
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume25
Issue number9
DOIs
StatePublished - 20 Sep 2004

Keywords

  • 1,1′-Binaphthyl-2,2′-diamine
  • Chiral separation
  • N-Acetyl-1- naphthylethylamide
  • Preparative liquid chromatography
  • Separation condition

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