Enantioseparation of tiropramide by HPLC

Jae Jeong Ryoo; Kyu Sung Heo; Eun Soon Choi; Jung Hag Park; Wonjae Lee

doi:10.1002/chir.20050

Enantioseparation of tiropramide by HPLC

Jae Jeong Ryoo, Kyu Sung Heo, Eun Soon Choi, Jung Hag Park, Wonjae Lee

Department of Chemical Science Education

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

Original language	English
Pages (from-to)	S51-S54
Journal	Chirality
Volume	16
Issue number	SUPPL.
DOIs	https://doi.org/10.1002/chir.20050
State	Published - 2004

Keywords

Chiral stationary phase
Chromatographic condition
Enantioseparation
HPLC
Racemic tiropramide

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10.1002/chir.20050

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title = "Enantioseparation of tiropramide by HPLC",

abstract = "Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.",

keywords = "Chiral stationary phase, Chromatographic condition, Enantioseparation, HPLC, Racemic tiropramide",

author = "Ryoo, {Jae Jeong} and Heo, {Kyu Sung} and Choi, {Eun Soon} and Park, {Jung Hag} and Wonjae Lee",

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pages = "S51--S54",

journal = "Chirality",

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T1 - Enantioseparation of tiropramide by HPLC

AU - Ryoo, Jae Jeong

AU - Heo, Kyu Sung

AU - Choi, Eun Soon

AU - Park, Jung Hag

AU - Lee, Wonjae

PY - 2004

Y1 - 2004

N2 - Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

AB - Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

KW - Chiral stationary phase

KW - Chromatographic condition

KW - Enantioseparation

KW - HPLC

KW - Racemic tiropramide

UR - http://www.scopus.com/inward/record.url?scp=3242706768&partnerID=8YFLogxK

U2 - 10.1002/chir.20050

DO - 10.1002/chir.20050

M3 - Article

C2 - 15239073

AN - SCOPUS:3242706768

SN - 0899-0042

VL - 16

SP - S51-S54

JO - Chirality

JF - Chirality

IS - SUPPL.

ER -

Enantioseparation of tiropramide by HPLC

Abstract

Keywords

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