Enhanced biocompatibility of a Ni-Cr alloy prepared by selective laser melting: A preliminary in vitro study

Min Ho Hong; Takao Hanawa; Si Hoon Song; Bong Ki Min; Tae Yub Kwon

doi:10.1016/j.jmrt.2018.08.004

Enhanced biocompatibility of a Ni-Cr alloy prepared by selective laser melting: A preliminary in vitro study

Min Ho Hong, Takao Hanawa, Si Hoon Song, Bong Ki Min, Tae Yub Kwon

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Against a general consensus regarding the high toxicity and low biocompatibility of cast nickel-chromium (Ni-Cr) alloys, the in vitro biocompatibility of selective laser melting (SLM)-fabricated Ni-Cr alloys was investigated and compared with that of cast alloy. Using a single Ni-Cr alloy powder, two SLM alloys with high (SLM-a) and low (SML-b) porosity were prepared by adjusting the laser process parameters in addition to a cast alloy. The alloys were studied in terms of their microstructure, metal ion release, and cell response. All three alloys were composed of only the γ(face-centered cubic) phase. However, both SLM alloys showed more homogeneous dispersion of Ni, Cr, and molybdenum elements and finer grain formation than the cast alloy. Immersion test results indicated that both SLM alloys (in particular, SML-b) exhibited a significantly lower Ni ion release than the cast alloy (P < 0.001). A water-soluble tetrazolium salt-8 assay also showed that the viability of L929 mouse fibroblasts was significantly higher for both SLM groups (in particular, SML-b) than for the cast alloy group (P < 0.001). Thus, the combined results of this in vitro study suggest that the SLM-processed Ni-Cr alloys exhibited greatly enhanced biocompatibility in comparison with the cast alloy.

Original language	English
Pages (from-to)	1587-1592
Number of pages	6
Journal	Journal of Materials Research and Technology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.jmrt.2018.08.004
State	Published - Jan 2019

Keywords

Biocompatibility
Metallurgy
Microstructure
Ni-Cr alloy
Selective laser melting

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title = "Enhanced biocompatibility of a Ni-Cr alloy prepared by selective laser melting: A preliminary in vitro study",

abstract = "Against a general consensus regarding the high toxicity and low biocompatibility of cast nickel-chromium (Ni-Cr) alloys, the in vitro biocompatibility of selective laser melting (SLM)-fabricated Ni-Cr alloys was investigated and compared with that of cast alloy. Using a single Ni-Cr alloy powder, two SLM alloys with high (SLM-a) and low (SML-b) porosity were prepared by adjusting the laser process parameters in addition to a cast alloy. The alloys were studied in terms of their microstructure, metal ion release, and cell response. All three alloys were composed of only the γ(face-centered cubic) phase. However, both SLM alloys showed more homogeneous dispersion of Ni, Cr, and molybdenum elements and finer grain formation than the cast alloy. Immersion test results indicated that both SLM alloys (in particular, SML-b) exhibited a significantly lower Ni ion release than the cast alloy (P < 0.001). A water-soluble tetrazolium salt-8 assay also showed that the viability of L929 mouse fibroblasts was significantly higher for both SLM groups (in particular, SML-b) than for the cast alloy group (P < 0.001). Thus, the combined results of this in vitro study suggest that the SLM-processed Ni-Cr alloys exhibited greatly enhanced biocompatibility in comparison with the cast alloy.",

keywords = "Biocompatibility, Metallurgy, Microstructure, Ni-Cr alloy, Selective laser melting",

author = "Hong, {Min Ho} and Takao Hanawa and Song, {Si Hoon} and Min, {Bong Ki} and Kwon, {Tae Yub}",

note = "Publisher Copyright: {\textcopyright} 2018 Brazilian Metallurgical, Materials and Mining Association.",

year = "2019",

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T1 - Enhanced biocompatibility of a Ni-Cr alloy prepared by selective laser melting

T2 - A preliminary in vitro study

AU - Hong, Min Ho

AU - Hanawa, Takao

AU - Song, Si Hoon

AU - Min, Bong Ki

AU - Kwon, Tae Yub

PY - 2019/1

Y1 - 2019/1

N2 - Against a general consensus regarding the high toxicity and low biocompatibility of cast nickel-chromium (Ni-Cr) alloys, the in vitro biocompatibility of selective laser melting (SLM)-fabricated Ni-Cr alloys was investigated and compared with that of cast alloy. Using a single Ni-Cr alloy powder, two SLM alloys with high (SLM-a) and low (SML-b) porosity were prepared by adjusting the laser process parameters in addition to a cast alloy. The alloys were studied in terms of their microstructure, metal ion release, and cell response. All three alloys were composed of only the γ(face-centered cubic) phase. However, both SLM alloys showed more homogeneous dispersion of Ni, Cr, and molybdenum elements and finer grain formation than the cast alloy. Immersion test results indicated that both SLM alloys (in particular, SML-b) exhibited a significantly lower Ni ion release than the cast alloy (P < 0.001). A water-soluble tetrazolium salt-8 assay also showed that the viability of L929 mouse fibroblasts was significantly higher for both SLM groups (in particular, SML-b) than for the cast alloy group (P < 0.001). Thus, the combined results of this in vitro study suggest that the SLM-processed Ni-Cr alloys exhibited greatly enhanced biocompatibility in comparison with the cast alloy.

AB - Against a general consensus regarding the high toxicity and low biocompatibility of cast nickel-chromium (Ni-Cr) alloys, the in vitro biocompatibility of selective laser melting (SLM)-fabricated Ni-Cr alloys was investigated and compared with that of cast alloy. Using a single Ni-Cr alloy powder, two SLM alloys with high (SLM-a) and low (SML-b) porosity were prepared by adjusting the laser process parameters in addition to a cast alloy. The alloys were studied in terms of their microstructure, metal ion release, and cell response. All three alloys were composed of only the γ(face-centered cubic) phase. However, both SLM alloys showed more homogeneous dispersion of Ni, Cr, and molybdenum elements and finer grain formation than the cast alloy. Immersion test results indicated that both SLM alloys (in particular, SML-b) exhibited a significantly lower Ni ion release than the cast alloy (P < 0.001). A water-soluble tetrazolium salt-8 assay also showed that the viability of L929 mouse fibroblasts was significantly higher for both SLM groups (in particular, SML-b) than for the cast alloy group (P < 0.001). Thus, the combined results of this in vitro study suggest that the SLM-processed Ni-Cr alloys exhibited greatly enhanced biocompatibility in comparison with the cast alloy.

KW - Biocompatibility

KW - Metallurgy

KW - Microstructure

KW - Ni-Cr alloy

KW - Selective laser melting

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Enhanced biocompatibility of a Ni-Cr alloy prepared by selective laser melting: A preliminary in vitro study

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