Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism

Myun Soo Kim; Minjee Lee; Hanna Oh; Wonsang Seo; Gwang Seob Kim; O. Hyun Ban; Minhye Shin; Young Hoon Jung; Jungwoo Yang

doi:10.1186/s13765-021-00620-7

Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism

Myun Soo Kim, Minjee Lee, Hanna Oh, Wonsang Seo, Gwang Seob Kim, O. Hyun Ban, Minhye Shin, Young Hoon Jung, Jungwoo Yang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.

Original language	English
Article number	50
Journal	Applied Biological Chemistry
Volume	64
Issue number	1
DOIs	https://doi.org/10.1186/s13765-021-00620-7
State	Published - Dec 2021

Keywords

Ceramides
Glucosylceramidase
Probiotics
Skin health
Sphingomyelinase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13765-021-00620-7

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title = "Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism",

abstract = "The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.",

keywords = "Ceramides, Glucosylceramidase, Probiotics, Skin health, Sphingomyelinase",

author = "Kim, {Myun Soo} and Minjee Lee and Hanna Oh and Wonsang Seo and Kim, {Gwang Seob} and Ban, {O. Hyun} and Minhye Shin and Jung, {Young Hoon} and Jungwoo Yang",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s13765-021-00620-7",

language = "English",

volume = "64",

journal = "Applied Biological Chemistry",

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AU - Kim, Myun Soo

AU - Lee, Minjee

AU - Oh, Hanna

AU - Seo, Wonsang

AU - Kim, Gwang Seob

AU - Ban, O. Hyun

AU - Shin, Minhye

AU - Jung, Young Hoon

AU - Yang, Jungwoo

PY - 2021/12

Y1 - 2021/12

N2 - The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.

AB - The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.

KW - Ceramides

KW - Glucosylceramidase

KW - Probiotics

KW - Skin health

KW - Sphingomyelinase

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DO - 10.1186/s13765-021-00620-7

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SN - 2468-0834

VL - 64

JO - Applied Biological Chemistry

JF - Applied Biological Chemistry

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ER -

Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism

Abstract

Keywords

UN SDGs

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