TY - JOUR
T1 - Enhanced guided bone regeneration by asymmetrically porous PCL/pluronic F127 membrane and ultrasound stimulation
AU - Oh, Se Heang
AU - Kim, Tae Ho
AU - Chun, So Young
AU - Park, Eui Kyun
AU - Lee, Jin Ho
PY - 2012
Y1 - 2012
N2 - Recently, we developed a novel method for fabricating a guided bone regeneration (GBR) membrane with an asymmetrical pore structure and hydrophilicity by an immersion precipitation method. Results from an animal study, in a cranial defect model in rats, indicated that the unique asymmetrically porous GBR membrane would provide a good environment for bone regeneration. In the present study, we applied low intensity pulsed ultrasound as a simple and non-invasive stimulus to an asymmetrically porous polycaprolactone (PCL)/Pluronic F127 GBR membrane-implanted site transcutaneously in rats to investigate the feasibility of using ultrasound to stimulate enhanced bone regeneration through the membrane. It was observed that the ultrasound-stimulated PCL/F127 GBR membrane group had much faster bone regeneration behavior than a PCL/F127 membrane group w/o ultrasound or a control group (w/o membrane and ultrasound). The greater bone regeneration behavior in the GBR membrane/ultrasound group may be caused by a synergistic effect of the asymmetrically porous PCL/F127 membrane with unique properties (selective permeability, hydrophilicity and osteoconductivity), and the stimulatory effect of ultrasound (induction of angiogenesis and osteogenesis of cells).
AB - Recently, we developed a novel method for fabricating a guided bone regeneration (GBR) membrane with an asymmetrical pore structure and hydrophilicity by an immersion precipitation method. Results from an animal study, in a cranial defect model in rats, indicated that the unique asymmetrically porous GBR membrane would provide a good environment for bone regeneration. In the present study, we applied low intensity pulsed ultrasound as a simple and non-invasive stimulus to an asymmetrically porous polycaprolactone (PCL)/Pluronic F127 GBR membrane-implanted site transcutaneously in rats to investigate the feasibility of using ultrasound to stimulate enhanced bone regeneration through the membrane. It was observed that the ultrasound-stimulated PCL/F127 GBR membrane group had much faster bone regeneration behavior than a PCL/F127 membrane group w/o ultrasound or a control group (w/o membrane and ultrasound). The greater bone regeneration behavior in the GBR membrane/ultrasound group may be caused by a synergistic effect of the asymmetrically porous PCL/F127 membrane with unique properties (selective permeability, hydrophilicity and osteoconductivity), and the stimulatory effect of ultrasound (induction of angiogenesis and osteogenesis of cells).
KW - Asymmetrically porous membrane
KW - Guided bone regeneration
KW - Physical stimulation
KW - Selective permeability
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84867225904&partnerID=8YFLogxK
U2 - 10.1163/092050611X589518
DO - 10.1163/092050611X589518
M3 - Article
C2 - 21888761
AN - SCOPUS:84867225904
SN - 0920-5063
VL - 23
SP - 1673
EP - 1686
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
IS - 13
ER -