Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis.

Young Bae Seu; Yung Hee Kho

doi:10.1016/S0040-4039(00)60920-6

Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis.

Young Bae Seu, Yung Hee Kho

School of Life Science and Biotechnology

Korea Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Asymmetric hydrolysis of geminally disubstituted achiral diacetate 2 with lipase PPL yielded optically active (R)-(-)-2-acetoxymethylglycidol 3 and its reduction gave compound 6, useful as the tert-alcohol chiral building block.

Original language	English
Pages (from-to)	7015-7016
Number of pages	2
Journal	Tetrahedron Letters
Volume	33
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(00)60920-6
State	Published - 10 Nov 1992

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@article{dcf5f820d8204584abdcb6f6d62b7d68,

title = "Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis.",

abstract = "Asymmetric hydrolysis of geminally disubstituted achiral diacetate 2 with lipase PPL yielded optically active (R)-(-)-2-acetoxymethylglycidol 3 and its reduction gave compound 6, useful as the tert-alcohol chiral building block.",

author = "Seu, {Young Bae} and Kho, {Yung Hee}",

year = "1992",

month = nov,

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doi = "10.1016/S0040-4039(00)60920-6",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis.

AU - Seu, Young Bae

AU - Kho, Yung Hee

PY - 1992/11/10

Y1 - 1992/11/10

N2 - Asymmetric hydrolysis of geminally disubstituted achiral diacetate 2 with lipase PPL yielded optically active (R)-(-)-2-acetoxymethylglycidol 3 and its reduction gave compound 6, useful as the tert-alcohol chiral building block.

AB - Asymmetric hydrolysis of geminally disubstituted achiral diacetate 2 with lipase PPL yielded optically active (R)-(-)-2-acetoxymethylglycidol 3 and its reduction gave compound 6, useful as the tert-alcohol chiral building block.

UR - http://www.scopus.com/inward/record.url?scp=0026485015&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)60920-6

DO - 10.1016/S0040-4039(00)60920-6

M3 - Article

AN - SCOPUS:0026485015

SN - 0040-4039

VL - 33

SP - 7015

EP - 7016

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis.

Abstract

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