Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma

Tae Su Han; Keun Hur; Hyun Soo Cho; Hyun Seung Ban

doi:10.3390/cancers12092622

Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma

Tae Su Han
, Keun Hur
, Hyun Soo Cho
, Hyun Seung Ban

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Review article › peer-review

151 Scopus citations

Abstract

The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.

Original language	English
Article number	2622
Pages (from-to)	1-17
Number of pages	17
Journal	Cancers
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/cancers12092622
State	Published - Sep 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Circular RNA
Competing endogenous RNA
Hepatocellular carcinoma
Long non-coding RNA
MicroRNA

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10.3390/cancers12092622

Cite this

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title = "Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma",

abstract = "The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.",

keywords = "Circular RNA, Competing endogenous RNA, Hepatocellular carcinoma, Long non-coding RNA, MicroRNA",

author = "Han, \{Tae Su\} and Keun Hur and Cho, \{Hyun Soo\} and Ban, \{Hyun Seung\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = sep,

doi = "10.3390/cancers12092622",

language = "English",

volume = "12",

pages = "1--17",

journal = "Cancers",

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TY - JOUR

T1 - Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma

AU - Han, Tae Su

AU - Hur, Keun

AU - Cho, Hyun Soo

AU - Ban, Hyun Seung

PY - 2020/9

Y1 - 2020/9

N2 - The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.

AB - The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.

KW - Circular RNA

KW - Competing endogenous RNA

KW - Hepatocellular carcinoma

KW - Long non-coding RNA

KW - MicroRNA

UR - https://www.scopus.com/pages/publications/85090832205

U2 - 10.3390/cancers12092622

DO - 10.3390/cancers12092622

M3 - Review article

AN - SCOPUS:85090832205

SN - 2072-6694

VL - 12

SP - 1

EP - 17

JO - Cancers

JF - Cancers

IS - 9

M1 - 2622

ER -

Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma

Abstract

UN SDGs

Keywords

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