Erratum to “Comprehensive characterization of metabolic, inflammatory and fibrotic changes in a mouse model of diet-derived nonalcoholic steatohepatitis” [The Journal of Nutritional Biochemistry Volume 85 (2020) 108463] (The Journal of Nutritional Biochemistry (2020) 85, (S0955286320304952), (10.1016/j.jnutbio.2020.108463))

The publisher regrets Incorrection 3.1. Time course for the changes in body weights and serum lipids in mice fed the HF/HS/HC diet It is important to appreciate when three important NASH features, namely, steatosis, inflammation and fibrosis, occur during a feeding study to design a mouse feeding study to capture any of those events of interest. We sought to determine in vivo time-course for the development of metabolic, inflammatory, and fibrotic events in male C57BL/6J mice fed a diet high in fat, sucrose, and cholesterol. Also, we aimed at gaining insight into the link between fibrosis and inflammation in the adipose tissue during the development of obesity-induced metabolic dysfunctions, inflammation, and fibrosis in the liver. The establishment of a mouse model of NASH with a strong manifestation of liver fibrosis with a thorough evaluation of pathological processes is needed to study the pathophysiology of NASH as well as new therapeutic drug developments. Supplementary Fig. 1. Correction 3.1. Time-course for the changes in body weights and serum lipids in mice fed the HF/HS/HC diet Our previous study showed that a diet high in fat, sucrose, and cholesterol induced the features of NASH with the evident manifestation of fibrosis in a relatively short period compared with others in the literature [2]. It is important to appreciate when three important NASH features, namely steatosis, inflammation, and fibrosis, occurs during a feeding study to design a mouse feeding study to capture any of those events of interest. We determined time points at which body weights and serum parameters of metabolic dysfunctions were significantly altered by the diet during 16 weeks with 2 weeks of the interval. Body weights of mice were significantly increased only after 4 weeks on the HF/HS/HC diet and continuously increased throughout 16 weeks (Fig. 1A). Daily food intake was not significantly different during the 16 weeks experimental period (Supplementary Fig. 1). Serum TC levels were modestly but significantly increased, whereas serum TG concentrations were significantly decreased and remained low throughout the rest of the feeding period (Fig. 1B and C). Serum FFA and glucose levels were minimally altered, but serum insulin showed a significant increase at week 12 (Fig. 1D-F). Also, HOMA-IR showed gradual increase in insulin resistance 16 weeks experimental period (Fig. 1G). The publisher would like to apologise for any inconvenience caused.