Erratum: Ultrasonic Neuromodulation via Astrocytic TRPA1 (Current Biology (2019) 29(20) (3386–3401.e8), (S0960982219310371), (10.1016/j.cub.2019.08.021))

(Current Biology 29, 3386–3401.e1–e8; October 21, 2019) It has been brought to our attention that some of the language in our paper could be misunderstood, leading to the conclusion that TRPA1 directly senses and is activated by low-intensity, low-frequency ultrasound (LILFU). Though this is our working hypothesis and our data are consistent with this possibility, we did not intend to make such a strong claim. Indeed, in the discussion we leave open the possibility that TRPA1 is directly activated by LILFU. In hindsight, two sentences in the paper could have a potential to be misleading, so we wish to make the following corrections below. Our intention was to emphasize that LILFU activates the astrocyte directly, not TRPA1 per se. The titles of the second part of the Result section and Figure 3 have been changed from “LILFU Activates Astrocytic TRPA1 Directly and Neuronal NMDAR Indirectly” to “LILFU Activates Astrocytes Directly via TRPA1 and Neurons Indirectly via NMDAR.” At the end of the Results section, the sentence, “Based on these results, we demonstrate that LILFU activates astrocytic TRPA1 directly and glutamate releasing Best1 indirectly through Ca²⁺ to target synaptic NMDAR, leading to neuronal firing (Figure 7),” has been removed and replaced by, “Based on these results, we demonstrate that LILFU stimulates astrocytic TRPA1, which results in activation of glutamate-releasing Best1 through Ca²⁺ to target synaptic NMDAR, leading to neuronal firing (Figure 7).” The authors declare that these corrections do not affect the quality of the data, analyses, or conclusions of the paper.