Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

Jieun Kim; Hyebin Koh; Xing Zhen; Dong Seok Lee; Hye Yeong Ha; Jong Hee Lee

doi:10.1016/j.scr.2021.102199

Establishment of iPSC (KRIBBi001-A) from CD34⁺ group O D-negative bone marrow blood

Jieun Kim, Hyebin Koh, Xing Zhen, Dong Seok Lee, Hye Yeong Ha, Jong Hee Lee

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5 Scopus citations

Abstract

Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD⁻) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD⁻ sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD⁻ somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.

Original language	English
Article number	102199
Journal	Stem Cell Research
Volume	51
DOIs	https://doi.org/10.1016/j.scr.2021.102199
State	Published - Mar 2021

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title = "Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood",

abstract = "Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD− sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD− somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.",

author = "Jieun Kim and Hyebin Koh and Xing Zhen and Lee, {Dong Seok} and Ha, {Hye Yeong} and Lee, {Jong Hee}",

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year = "2021",

month = mar,

doi = "10.1016/j.scr.2021.102199",

language = "English",

volume = "51",

journal = "Stem Cell Research",

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T1 - Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

AU - Kim, Jieun

AU - Koh, Hyebin

AU - Zhen, Xing

AU - Lee, Dong Seok

AU - Ha, Hye Yeong

AU - Lee, Jong Hee

PY - 2021/3

Y1 - 2021/3

N2 - Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD− sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD− somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.

AB - Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD− sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD− somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.

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U2 - 10.1016/j.scr.2021.102199

DO - 10.1016/j.scr.2021.102199

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AN - SCOPUS:85099927696

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VL - 51

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102199

ER -

Establishment of iPSC (KRIBBi001-A) from CD34⁺ group O D-negative bone marrow blood

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