Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Hyun Jae Jang; Hyun Mee Oh; Joo Tae Hwang; Mi Hwa Kim; Soyoung Lee; Kyungsook Jung; Young Ho Kim; Seung Woong Lee; Mun Chual Rho

doi:10.1016/j.phytochem.2016.08.001

Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Hyun Jae Jang, Hyun Mee Oh, Joo Tae Hwang, Mi Hwa Kim, Soyoung Lee, Kyungsook Jung, Young Ho Kim, Seung Woong Lee, Mun Chual Rho

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC₅₀ value of 1.1 μM.

Original language	English
Pages (from-to)	335-342
Number of pages	8
Journal	Phytochemistry
Volume	130
DOIs	https://doi.org/10.1016/j.phytochem.2016.08.001
State	Published - 1 Oct 2016

Keywords

Eudesmane sesquiterpenoids
IL-6
Inflammation
Lamiaceae
Salvia plebeia
STAT3

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10.1016/j.phytochem.2016.08.001

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title = "Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation",

abstract = "Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.",

keywords = "Eudesmane sesquiterpenoids, IL-6, Inflammation, Lamiaceae, Salvia plebeia, STAT3",

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doi = "10.1016/j.phytochem.2016.08.001",

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AU - Jang, Hyun Jae

AU - Oh, Hyun Mee

AU - Hwang, Joo Tae

AU - Kim, Mi Hwa

AU - Lee, Soyoung

AU - Jung, Kyungsook

AU - Kim, Young Ho

AU - Lee, Seung Woong

AU - Rho, Mun Chual

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AB - Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

KW - Eudesmane sesquiterpenoids

KW - IL-6

KW - Inflammation

KW - Lamiaceae

KW - Salvia plebeia

KW - STAT3

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ER -

Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Abstract

Keywords

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