Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Hyun Jae Jang; Hyun Mee Oh; Joo Tae Hwang; Mi Hwa Kim; Soyoung Lee; Kyungsook Jung; Young Ho Kim; Seung Woong Lee; Mun Chual Rho

doi:10.1016/j.phytochem.2016.08.001

Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Hyun Jae Jang
, Hyun Mee Oh
, Joo Tae Hwang
, Mi Hwa Kim
, Soyoung Lee
, Kyungsook Jung
, Young Ho Kim
, Seung Woong Lee
, Mun Chual Rho

Department of Innovative Pharmaceutical Sciences

Korea Research Institute of Bioscience and Biotechnology
Chungnam National University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC₅₀ value of 1.1 μM.

Original language	English
Pages (from-to)	335-342
Number of pages	8
Journal	Phytochemistry
Volume	130
DOIs	https://doi.org/10.1016/j.phytochem.2016.08.001
State	Published - 1 Oct 2016

Keywords

Eudesmane sesquiterpenoids
IL-6
Inflammation
Lamiaceae
Salvia plebeia
STAT3

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10.1016/j.phytochem.2016.08.001

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title = "Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation",

abstract = "Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.",

keywords = "Eudesmane sesquiterpenoids, IL-6, Inflammation, Lamiaceae, Salvia plebeia, STAT3",

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doi = "10.1016/j.phytochem.2016.08.001",

language = "English",

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AU - Jang, Hyun Jae

AU - Oh, Hyun Mee

AU - Hwang, Joo Tae

AU - Kim, Mi Hwa

AU - Lee, Soyoung

AU - Jung, Kyungsook

AU - Kim, Young Ho

AU - Lee, Seung Woong

AU - Rho, Mun Chual

PY - 2016/10/1

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N2 - Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

AB - Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

KW - Eudesmane sesquiterpenoids

KW - IL-6

KW - Inflammation

KW - Lamiaceae

KW - Salvia plebeia

KW - STAT3

UR - https://www.scopus.com/pages/publications/84995575923

U2 - 10.1016/j.phytochem.2016.08.001

DO - 10.1016/j.phytochem.2016.08.001

M3 - Article

C2 - 27506573

AN - SCOPUS:84995575923

SN - 0031-9422

VL - 130

SP - 335

EP - 342

JO - Phytochemistry

JF - Phytochemistry

ER -

Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Abstract

Keywords

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