Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

Dong Il Chung; Sookwan Jeong; Sylvatrie Danne Dinzouna-Boutamba; Hye Won Yang; Sang Geon Yeo; Yeonchul Hong; Youn Kyoung Goo

doi:10.1186/s12936-015-0845-6

Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

Dong Il Chung, Sookwan Jeong, Sylvatrie Danne Dinzouna-Boutamba, Hye Won Yang, Sang Geon Yeo, Yeonchul Hong, Youn Kyoung Goo

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. Methods: To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Results: Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Conclusions: Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

Original language	English
Article number	336
Journal	Malaria Journal
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12936-015-0845-6
State	Published - 1 Dec 2015

Keywords

Genetic diversity
Microsatellite marker
Multidrug resistant-1 gene
Plasmodium vivax

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12936-015-0845-6

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title = "Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel",

abstract = "Background: Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. Methods: To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Results: Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Conclusions: Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.",

keywords = "Genetic diversity, Microsatellite marker, Multidrug resistant-1 gene, Plasmodium vivax",

author = "Chung, {Dong Il} and Sookwan Jeong and Dinzouna-Boutamba, {Sylvatrie Danne} and Yang, {Hye Won} and Yeo, {Sang Geon} and Yeonchul Hong and Goo, {Youn Kyoung}",

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year = "2015",

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doi = "10.1186/s12936-015-0845-6",

language = "English",

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journal = "Malaria Journal",

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T1 - Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

AU - Chung, Dong Il

AU - Jeong, Sookwan

AU - Dinzouna-Boutamba, Sylvatrie Danne

AU - Yang, Hye Won

AU - Yeo, Sang Geon

AU - Hong, Yeonchul

AU - Goo, Youn Kyoung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. Methods: To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Results: Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Conclusions: Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

AB - Background: Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. Methods: To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Results: Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Conclusions: Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

KW - Genetic diversity

KW - Microsatellite marker

KW - Multidrug resistant-1 gene

KW - Plasmodium vivax

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ER -

Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

Abstract

Keywords

UN SDGs

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